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Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.
Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Guo H, et al. Among authors: chen l. Science. 2020 Oct 30;370(6516):eaay9097. doi: 10.1126/science.aay9097. Science. 2020. PMID: 33122357 Free PMC article.
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.
Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP. Truax AD, et al. Among authors: chen l. Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009. Cell Host Microbe. 2018. PMID: 30212649 Free PMC article.
Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells.
Mishima Y, Oka A, Liu B, Herzog JW, Eun CS, Fan TJ, Bulik-Sullivan E, Carroll IM, Hansen JJ, Chen L, Wilson JE, Fisher NC, Ting JP, Nochi T, Wahl A, Garcia JV, Karp CL, Sartor RB. Mishima Y, et al. Among authors: chen l. J Clin Invest. 2019 Jun 18;129(9):3702-3716. doi: 10.1172/JCI93820. J Clin Invest. 2019. PMID: 31211700 Free PMC article.
Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases.
Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. Chou WC, et al. Among authors: chen l, chen x. Nature. 2021 Apr;592(7856):E29. doi: 10.1038/s41586-021-03490-7. Nature. 2021. PMID: 33854241 No abstract available.
AIM2 in regulatory T cells restrains autoimmune diseases.
Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. Chou WC, et al. Among authors: chen l, chen x. Nature. 2021 Mar;591(7849):300-305. doi: 10.1038/s41586-021-03231-w. Epub 2021 Jan 27. Nature. 2021. PMID: 33505023 Free PMC article.
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. Chen ST, et al. Among authors: chen l, chen sy. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19. Cell Host Microbe. 2019. PMID: 30902577 Free PMC article.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP. Wilson JE, et al. Among authors: chen l. Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24. Nat Med. 2015. PMID: 26107252 Free PMC article.
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