Chen L - Search Results

1

Discovery of Irreversible p97 Inhibitors.

Ding R, Zhang T, Wilson DJ, Xie J, Williams J, Xu Y, Ye Y, Chen L. Ding R, et al. Among authors: chen l. J Med Chem. 2019 Mar 14;62(5):2814-2829. doi: 10.1021/acs.jmedchem.9b00144. Epub 2019 Mar 4. J Med Chem. 2019. PMID: 30830772

2

Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.

Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW. Rejman D, et al. Among authors: chen l. J Med Chem. 2006 Aug 10;49(16):5018-22. doi: 10.1021/jm060479r. J Med Chem. 2006. PMID: 16884314

3

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.

Bonnac L, Chen L, Pathak R, Gao G, Ming Q, Bennett E, Felczak K, Kullberg M, Patterson SE, Mazzola F, Magni G, Pankiewicz KW. Bonnac L, et al. Among authors: chen l. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1512-5. doi: 10.1016/j.bmcl.2007.01.012. Epub 2007 Jan 17. Bioorg Med Chem Lett. 2007. PMID: 17258457

4

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW. Chen L, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3152-5. doi: 10.1016/j.bmcl.2007.03.035. Epub 2007 Mar 15. Bioorg Med Chem Lett. 2007. PMID: 17395461

5

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.

Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW. Chen L, et al. J Med Chem. 2007 Nov 15;50(23):5743-51. doi: 10.1021/jm070568j. Epub 2007 Oct 24. J Med Chem. 2007. PMID: 17958343

6

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Chen L, Wilson D, Jayaram HN, Pankiewicz KW. Chen L, et al. J Med Chem. 2007 Dec 27;50(26):6685-91. doi: 10.1021/jm070864w. Epub 2007 Nov 27. J Med Chem. 2007. PMID: 18038969

7

Nicotinamide adenine dinucleotide based therapeutics.

Chen L, Petrelli R, Felczak K, Gao G, Bonnac L, Yu JS, Bennett EM, Pankiewicz KW. Chen L, et al. Curr Med Chem. 2008;15(7):650-70. doi: 10.2174/092986708783885282. Curr Med Chem. 2008. PMID: 18336280 Review.

8

Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.

Chen L, Petrelli R, Olesiak M, Wilson DJ, Labello NP, Pankiewicz KW. Chen L, et al. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. doi: 10.1016/j.bmc.2008.06.003. Epub 2008 Jun 10. Bioorg Med Chem. 2008. PMID: 18583139

9

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE 3rd, Bennett EM, Aldrich CC. Neres J, et al. Among authors: chen l. J Med Chem. 2008 Sep 11;51(17):5349-70. doi: 10.1021/jm800567v. Epub 2008 Aug 9. J Med Chem. 2008. PMID: 18690677 Free PMC article.

10

Mycophenolic acid analogs with a modified metabolic profile.

Chen L, Wilson DJ, Labello NP, Jayaram HN, Pankiewicz KW. Chen L, et al. Bioorg Med Chem. 2008 Oct 15;16(20):9340-5. doi: 10.1016/j.bmc.2008.08.062. Epub 2008 Aug 29. Bioorg Med Chem. 2008. PMID: 18809333

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