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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Sanchez M, et al. Among authors: chen l. Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861853 Free PMC article.
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.
Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK. Chen X, et al. Among authors: chen z, chen l. Mol Cancer Ther. 2019 May;18(5):886-899. doi: 10.1158/1535-7163.MCT-18-0918. Epub 2019 Mar 29. Mol Cancer Ther. 2019. PMID: 30926635 Free PMC article.
Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.
Zeng Z, Sun Z, Huang M, Zhang W, Liu J, Chen L, Chen F, Zhou Y, Lin J, Huang F, Xu L, Zhuang Z, Guo S, Alitongbieke G, Xie G, Xu Y, Lin B, Cao X, Su Y, Zhang XK, Zhou H. Zeng Z, et al. Among authors: chen l, chen f. Cancer Res. 2015 May 15;75(10):2049-60. doi: 10.1158/0008-5472.CAN-14-2435. Epub 2015 Mar 20. Cancer Res. 2015. PMID: 25795708 Free PMC article.
NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell.
Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y, Zhang L, Zhou F, Zhang XK, Zhou H. Chen F, et al. Among authors: chen j, chen l, chen y. Protein Cell. 2015 Sep;6(9):654-666. doi: 10.1007/s13238-015-0178-9. Epub 2015 Jul 9. Protein Cell. 2015. PMID: 26156677 Free PMC article.
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