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A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.
Xiong B, Gui CS, Xu XY, Luo C, Chen J, Luo HB, Chen LL, Li GW, Sun T, Yu CY, Yue LD, Duan WH, Shen JK, Qin L, Shi TL, Li YX, Chen KX, Luo XM, Shen X, Shen JH, Jiang HL. Xiong B, et al. Among authors: chen j, chen ll, chen kx. Acta Pharmacol Sin. 2003 Jun;24(6):497-504. Acta Pharmacol Sin. 2003. PMID: 12791174 Free article.
Binding analyses between Human PPARgamma-LBD and ligands.
Yu C, Chen L, Luo H, Chen J, Cheng F, Gui C, Zhang R, Shen J, Chen K, Jiang H, Shen X. Yu C, et al. Among authors: chen j, chen k, chen l. Eur J Biochem. 2004 Jan;271(2):386-97. doi: 10.1046/j.1432-1033.2003.03937.x. Eur J Biochem. 2004. PMID: 14717706 Free article.
Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations.
Chen S, Chen L, Tan J, Chen J, Du L, Sun T, Shen J, Chen K, Jiang H, Shen X. Chen S, et al. Among authors: chen j, chen k, chen l. J Biol Chem. 2005 Jan 7;280(1):164-73. doi: 10.1074/jbc.M408211200. Epub 2004 Oct 26. J Biol Chem. 2005. PMID: 15507456 Free PMC article.
Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K, Shen J, Shen X, Jiang H. Chen L, et al. Among authors: chen j, chen k. J Virol. 2005 Jun;79(11):7095-103. doi: 10.1128/JVI.79.11.7095-7103.2005. J Virol. 2005. PMID: 15890949 Free PMC article.
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