Chen KW - Search Results

1

Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation.

Fischer FA, Chen KW, Bezbradica JS. Fischer FA, et al. Among authors: chen kw. Front Immunol. 2021 Apr 2;12:661162. doi: 10.3389/fimmu.2021.661162. eCollection 2021. Front Immunol. 2021. PMID: 33868312 Free PMC article. Review.

2

The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists.

Chen KW, Bezbradica JS, Groß CJ, Wall AA, Sweet MJ, Stow JL, Schroder K. Chen KW, et al. Eur J Immunol. 2016 Apr;46(4):1004-10. doi: 10.1002/eji.201545943. Epub 2016 Feb 1. Eur J Immunol. 2016. PMID: 27062120 Free article.

3

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.

Boucher D, Monteleone M, Coll RC, Chen KW, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K. Boucher D, et al. Among authors: chen kw. J Exp Med. 2018 Mar 5;215(3):827-840. doi: 10.1084/jem.20172222. Epub 2018 Feb 6. J Exp Med. 2018. PMID: 29432122 Free PMC article.

4

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.

Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica JS, Vince JE, Schroder K. Chen KW, et al. J Immunol. 2018 May 15;200(10):3341-3346. doi: 10.4049/jimmunol.1701620. Epub 2018 Apr 16. J Immunol. 2018. PMID: 29661823

5

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K. Monteleone M, et al. Among authors: chen kw. Cell Rep. 2018 Aug 7;24(6):1425-1433. doi: 10.1016/j.celrep.2018.07.027. Cell Rep. 2018. PMID: 30089254 Free article.

6

Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. Chen KW, et al. Sci Immunol. 2018 Aug 24;3(26):eaar6676. doi: 10.1126/sciimmunol.aar6676. Sci Immunol. 2018. PMID: 30143554

7

Inflammasome and gasdermin signaling in neutrophils.

Yow SJ, Yeap HW, Chen KW. Yow SJ, et al. Among authors: chen kw. Mol Microbiol. 2022 May;117(5):961-972. doi: 10.1111/mmi.14891. Epub 2022 Mar 16. Mol Microbiol. 2022. PMID: 35244299 Free article. Review.

8

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.

Demarco B, Grayczyk JP, Bjanes E, Le Roy D, Tonnus W, Assenmacher CA, Radaelli E, Fettrelet T, Mack V, Linkermann A, Roger T, Brodsky IE, Chen KW, Broz P. Demarco B, et al. Among authors: chen kw. Sci Adv. 2020 Nov 18;6(47):eabc3465. doi: 10.1126/sciadv.abc3465. Print 2020 Nov. Sci Adv. 2020. PMID: 33208362 Free PMC article.

9

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling.

Chen KW, Demarco B, Ramos S, Heilig R, Goris M, Grayczyk JP, Assenmacher CA, Radaelli E, Joannas LD, Henao-Mejia J, Tacchini-Cottier F, Brodsky IE, Broz P. Chen KW, et al. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2101189118. doi: 10.1073/pnas.2101189118. Proc Natl Acad Sci U S A. 2021. PMID: 34260403 Free PMC article.

10

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.

Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Among authors: chen kw. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.

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