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Targeting TGF-β signaling in cancer.
Katz LH, Li Y, Chen JS, Muñoz NM, Majumdar A, Chen J, Mishra L. Katz LH, et al. Among authors: chen j, chen js. Expert Opin Ther Targets. 2013 Jul;17(7):743-60. doi: 10.1517/14728222.2013.782287. Epub 2013 May 7. Expert Opin Ther Targets. 2013. PMID: 23651053 Free PMC article. Review.
Aurora B kinase phosphorylates and instigates degradation of p53.
Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Gully CP, et al. Among authors: chen j, chen js. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):E1513-22. doi: 10.1073/pnas.1110287109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611192 Free PMC article.
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.
Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Fuentes-Mattei E, et al. Among authors: chen j, chen js. J Natl Cancer Inst. 2014 Jun 23;106(7):dju158. doi: 10.1093/jnci/dju158. Print 2014 Jul. J Natl Cancer Inst. 2014. PMID: 24957076 Free PMC article.
CSN6 drives carcinogenesis by positively regulating Myc stability.
Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. Chen J, et al. Among authors: chen js. Nat Commun. 2014 Nov 14;5:5384. doi: 10.1038/ncomms6384. Nat Commun. 2014. PMID: 25395170 Free PMC article.
TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L. Chen J, et al. Among authors: chen js. J Clin Invest. 2016 Feb;126(2):527-42. doi: 10.1172/JCI80937. Epub 2016 Jan 19. J Clin Invest. 2016. PMID: 26784546 Free PMC article.
Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas.
Chen J, Raju GS, Jogunoori W, Menon V, Majumdar A, Chen JS, Gi YJ, Jeong YS, Phan L, Belkin M, Gu S, Kundra S, Mistry NA, Zhang J, Su X, Li S, Lin SH, Javle M, McMurray JS, Rahlfs TF, Mishra B, White J, Rashid A, Beauchemin N, Weston BR, Shafi MA, Stroehlein JR, Davila M, Akbani R, Weinstein JN, Wu X, Mishra L. Chen J, et al. Among authors: chen js. PLoS One. 2016 Apr 21;11(4):e0153933. doi: 10.1371/journal.pone.0153933. eCollection 2016. PLoS One. 2016. PMID: 27100181 Free PMC article.
The somatic mutation landscape of premalignant colorectal adenoma.
Lin SH, Raju GS, Huff C, Ye Y, Gu J, Chen JS, Hildebrandt MAT, Liang H, Menter DG, Morris J, Hawk E, Stroehlein JR, Futreal A, Kopetz S, Mishra L, Wu X. Lin SH, et al. Among authors: chen js. Gut. 2018 Jul;67(7):1299-1305. doi: 10.1136/gutjnl-2016-313573. Epub 2017 Jun 12. Gut. 2018. PMID: 28607096 Free PMC article.
Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway.
Chen J, Zaidi S, Rao S, Chen JS, Phan L, Farci P, Su X, Shetty K, White J, Zamboni F, Wu X, Rashid A, Pattabiraman N, Mazumder R, Horvath A, Wu RC, Li S, Xiao C, Deng CX, Wheeler DA, Mishra B, Akbani R, Mishra L. Chen J, et al. Among authors: chen js. Gastroenterology. 2018 Jan;154(1):195-210. doi: 10.1053/j.gastro.2017.09.007. Epub 2017 Sep 15. Gastroenterology. 2018. PMID: 28918914 Free PMC article.
Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling.
Chen J, Mitra A, Li S, Song S, Nguyen BN, Chen JS, Shin JH, Gough NR, Lin P, Obias V, He AR, Yao Z, Malta TM, Noushmehr H, Latham PS, Su X, Rashid A, Mishra B, Wu RC, Mishra L. Chen J, et al. Among authors: chen js. Cancer Res. 2020 May 1;80(9):1819-1832. doi: 10.1158/0008-5472.CAN-19-3116. Epub 2020 Mar 3. Cancer Res. 2020. PMID: 32127355 Free PMC article.
2,937 results