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Direct kinetochore-spindle pole connections are not required for chromosome segregation.
Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A. Sikirzhytski V, et al. Among authors: chen jk. J Cell Biol. 2014 Jul 21;206(2):231-43. doi: 10.1083/jcb.201401090. Epub 2014 Jul 14. J Cell Biol. 2014. PMID: 25023516 Free PMC article.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Firestone AJ, et al. Among authors: chen jk. Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936. Nature. 2012. PMID: 22425997 Free PMC article.
Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.
See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK. See SK, et al. Among authors: chen jk. ACS Chem Biol. 2016 Jan 15;11(1):53-60. doi: 10.1021/acschembio.5b00895. Epub 2015 Nov 11. ACS Chem Biol. 2016. PMID: 26555042 Free PMC article.
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Steinman JB, et al. Among authors: chen jk. Elife. 2017 May 19;6:e25174. doi: 10.7554/eLife.25174. Elife. 2017. PMID: 28524820 Free PMC article.
Thinking big with small molecules.
Mruk K, Chen JK. Mruk K, et al. Among authors: chen jk. J Cell Biol. 2015 Apr 13;209(1):7-9. doi: 10.1083/jcb.201501084. J Cell Biol. 2015. PMID: 25869661 Free PMC article.
Lanthanide-Based Optical Probes of Biological Systems.
Cho U, Chen JK. Cho U, et al. Among authors: chen jk. Cell Chem Biol. 2020 Aug 20;27(8):921-936. doi: 10.1016/j.chembiol.2020.07.009. Epub 2020 Jul 30. Cell Chem Biol. 2020. PMID: 32735780 Free PMC article. Review.
985 results