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A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta.
Carter B, Huang P, Liu G, Liang Y, Lin PJC, Peng BH, McKay LGA, Dimitrakakis A, Hsu J, Tat V, Saenkham-Huntsinger P, Chen J, Kaseke C, Gaiha GD, Xu Q, Griffiths A, Tam YK, Tseng CK, Gifford DK. Carter B, et al. Among authors: chen j. Front Immunol. 2023 Mar 9;14:1135815. doi: 10.3389/fimmu.2023.1135815. eCollection 2023. Front Immunol. 2023. PMID: 36969239 Free PMC article.
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants.
Ye Z, Bonam SR, McKay LGA, Plante JA, Walker J, Zhao Y, Huang C, Chen J, Xu C, Li Y, Liu L, Harmon J, Gao S, Song D, Zhang Z, Plante KS, Griffiths A, Chen J, Hu H, Xu Q. Ye Z, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2311752120. doi: 10.1073/pnas.2311752120. Epub 2023 Dec 22. Proc Natl Acad Sci U S A. 2023. PMID: 38134199 Free PMC article.
Real-time evaluation of signal accuracy in wastewater surveillance of pathogens with high rates of mutation.
Thakali O, Mercier É, Eid W, Wellman M, Brasset-Gorny J, Overton AK, Knapp JJ, Manuel D, Charles TC, Goodridge L, Arts EJ, Poon AFY, Brown RS, Graber TE, Delatolla R, DeGroot CT; Ontario Wastewater Surveillance Consortium. Thakali O, et al. Sci Rep. 2024 Feb 14;14(1):3728. doi: 10.1038/s41598-024-54319-y. Sci Rep. 2024. PMID: 38355869 Free PMC article.
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