Chen J - Search Results

1

Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations.

Wang L, Xue W, Zhang H, Gao R, Qiu H, Wei J, Zhou L, Lei YN, Wu X, Li X, Liu C, Wu J, Chen Q, Ma H, Huang X, Cai C, Zhang Y, Yang B, Yin H, Yang L, Chen J. Wang L, et al. Among authors: chen j, chen q. Nat Cell Biol. 2021 May;23(5):552-563. doi: 10.1038/s41556-021-00671-4. Epub 2021 May 10. Nat Cell Biol. 2021. PMID: 33972728

2

Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus.

Yang L, Lee O, Chen J, Chen J, Chang CC, Zhou P, Wang ZZ, Ma HH, Sha HF, Feng JX, Wang Y, Yang XY, Wang L, Dong R, Ornvold K, Li BL, Chang TY. Yang L, et al. Among authors: chen j. J Biol Chem. 2004 Oct 29;279(44):46253-62. doi: 10.1074/jbc.M408155200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15319423 Free article.

3

Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone.

Yang L, Yang JB, Chen J, Yu GY, Zhou P, Lei L, Wang ZZ, Cy Chang C, Yang XY, Chang TY, Li BL. Yang L, et al. Among authors: chen j. Cell Res. 2004 Aug;14(4):315-23. doi: 10.1038/sj.cr.7290231. Cell Res. 2004. PMID: 15353128

4

RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform.

Chen J, Zhao XN, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL. Chen J, et al. Cell Res. 2008 Sep;18(9):921-36. doi: 10.1038/cr.2008.66. Cell Res. 2008. PMID: 18542101 Free PMC article.

5

Highly efficient and precise base editing in discarded human tripronuclear embryos.

Li G, Liu Y, Zeng Y, Li J, Wang L, Yang G, Chen D, Shang X, Chen J, Huang X, Liu J. Li G, et al. Among authors: chen j, chen d. Protein Cell. 2017 Oct;8(10):776-779. doi: 10.1007/s13238-017-0458-7. Protein Cell. 2017. PMID: 28825190 Free PMC article. No abstract available.

6

Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor.

Wang L, Xue W, Yan L, Li X, Wei J, Chen M, Wu J, Yang B, Yang L, Chen J. Wang L, et al. Among authors: chen j, chen m. Cell Res. 2017 Oct;27(10):1289-1292. doi: 10.1038/cr.2017.111. Epub 2017 Aug 29. Cell Res. 2017. PMID: 28849781 Free PMC article. No abstract available.

7

APOBEC: From mutator to editor.

Yang B, Li X, Lei L, Chen J. Yang B, et al. Among authors: chen j. J Genet Genomics. 2017 Sep 20;44(9):423-437. doi: 10.1016/j.jgg.2017.04.009. Epub 2017 Aug 7. J Genet Genomics. 2017. PMID: 28964683 Review.

8

APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.

Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B, Yang L, Chen J. Lei L, et al. Among authors: chen j, chen h. Nat Struct Mol Biol. 2018 Jan;25(1):45-52. doi: 10.1038/s41594-017-0004-6. Epub 2017 Dec 11. Nat Struct Mol Biol. 2018. PMID: 29323274

9

Base editing with a Cpf1-cytidine deaminase fusion.

Li X, Wang Y, Liu Y, Yang B, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X, Yang L, Chen J. Li X, et al. Among authors: chen j. Nat Biotechnol. 2018 Apr;36(4):324-327. doi: 10.1038/nbt.4102. Epub 2018 Mar 19. Nat Biotechnol. 2018. PMID: 29553573

10

BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity.

Jiang W, Feng S, Huang S, Yu W, Li G, Yang G, Liu Y, Zhang Y, Zhang L, Hou Y, Chen J, Chen J, Huang X. Jiang W, et al. Among authors: chen j. Cell Res. 2018 Aug;28(8):855-861. doi: 10.1038/s41422-018-0052-4. Epub 2018 Jun 6. Cell Res. 2018. PMID: 29875396 Free PMC article.

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