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Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.
Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM, Zhang ZZ, Cai XF, Hu Y, Zhang WL, Long QX, Ren F, Zhou HZ, Huang AL, Chen J. Cheng ST, et al. Among authors: chen j, chen wx. J Hepatol. 2021 Mar;74(3):522-534. doi: 10.1016/j.jhep.2020.09.019. Epub 2020 Sep 25. J Hepatol. 2021. PMID: 32987030 Free article.
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J. Ren JH, et al. Among authors: chen j, chen wx. Hepatology. 2018 Oct;68(4):1260-1276. doi: 10.1002/hep.29912. Epub 2018 Jul 25. Hepatology. 2018. PMID: 29624717
A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A.
Zhou L, Ren JH, Cheng ST, Xu HM, Chen WX, Chen DP, Wong VKW, Law BYK, Liu Y, Cai XF, Tang H, Yu HB, Hu JL, Hu Y, Zhou HZ, Ren F, He L, Hu ZW, Jiang H, Xu HY, Huang AL, Chen J. Zhou L, et al. Among authors: chen j, chen wx, chen dp. Hepatology. 2019 May;69(5):1885-1902. doi: 10.1002/hep.30497. Epub 2019 Mar 15. Hepatology. 2019. PMID: 30614547
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Li WY, Zhou HZ, Chen Y, Cai XF, Tang H, Ren JH, Wai Wong VK, Kwan Law BY, Chen Y, Cheng ST, Yu HB, Cai HY, Chen WX, Tang N, Zhang WL, Tao NN, Yang QX, Ren F, He L, Jiang H, Huang AL, Chen J. Li WY, et al. Among authors: chen j, chen wx, chen y. Cancer Lett. 2019 Jun 1;451:156-167. doi: 10.1016/j.canlet.2019.02.053. Epub 2019 Mar 10. Cancer Lett. 2019. PMID: 30867140
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