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The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Among authors: chen t, chen h. Cell Death Differ. 2023 Apr;30(4):1033-1046. doi: 10.1038/s41418-023-01122-3. Epub 2023 Feb 4. Cell Death Differ. 2023. PMID: 36739334 Free PMC article.
Design and characterization of a heterobifunctional degrader of KEAP1.
Chen H, Nguyen NH, Magtoto CM, Cobbold SA, Bidgood GM, Meza Guzman LG, Richardson LW, Corbin J, Au AE, Lechtenberg BC, Feltham R, Sutherland KD, Grohmann C, Nicholson SE, Sleebs BE. Chen H, et al. Redox Biol. 2023 Feb;59:102552. doi: 10.1016/j.redox.2022.102552. Epub 2022 Nov 26. Redox Biol. 2023. PMID: 36473314 Free PMC article.
Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Among authors: chen t, chen h. Cell Death Differ. 2023 Apr;30(4):1096. doi: 10.1038/s41418-023-01137-w. Cell Death Differ. 2023. PMID: 36828917 Free PMC article. No abstract available.
Structure guided studies of the interaction between PTP1B and JAK.
Morris R, Keating N, Tan C, Chen H, Laktyushin A, Saiyed T, Liau NPD, Nicola NA, Tiganis T, Kershaw NJ, Babon JJ. Morris R, et al. Among authors: chen h. Commun Biol. 2023 Jun 14;6(1):641. doi: 10.1038/s42003-023-05020-9. Commun Biol. 2023. PMID: 37316570 Free PMC article.
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