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Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
Tang J, Qi X, Mercola D, Han J, Chen G. Tang J, et al. Among authors: chen g. J Biol Chem. 2005 Jun 24;280(25):23910-7. doi: 10.1074/jbc.M500699200. Epub 2005 Apr 25. J Biol Chem. 2005. PMID: 15851477 Free PMC article.
Whereas the ERK MAPK pathway is required for Ras transformation, our previous works established that the p38 activity is inhibitory to Ras signaling in both experimental and ras-mutated cancer cells (Chen, G., Hitomi, M., Han, J., and Stacey, D. W. (2000) J. Biol. C …
Whereas the ERK MAPK pathway is required for Ras transformation, our previous works established that the p38 activity is inhibitory to Ras s …
Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity.
Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G. Li QP, et al. Among authors: chen g. J Biol Chem. 2007 Jan 19;282(3):1544-51. doi: 10.1074/jbc.M604052200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121851 Free article.
., Schultz, R. M., Maitra, R. K., Han, J., DeLuca, H. F., and Chen, G. (2002) J. Biol. Chem. 277, 25884-25892) and VDR inhibits cell death in response to p38 MAPK activation (Qi, X., Tang, J., Pramanik, R., Schultz, R. M., Shirasawa, S., Sasazuki, T., Han, J., and …
., Schultz, R. M., Maitra, R. K., Han, J., DeLuca, H. F., and Chen, G. (2002) J. Biol. Chem. 277, 25884-25892) and VDR inhibit …
p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.
Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G. Qi X, et al. Among authors: chen g. J Biol Chem. 2012 Apr 27;287(18):14681-91. doi: 10.1074/jbc.M112.349357. Epub 2012 Mar 7. J Biol Chem. 2012. PMID: 22399296 Free PMC article.
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