Chen D - Search Results

1

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.

He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D. He M, et al. Among authors: chen d. Cell Metab. 2020 Mar 3;31(3):580-591.e5. doi: 10.1016/j.cmet.2020.01.009. Epub 2020 Feb 6. Cell Metab. 2020. PMID: 32032542 Free PMC article.

2

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.

Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Qiu X, et al. Among authors: chen d. Cell Metab. 2010 Dec 1;12(6):662-7. doi: 10.1016/j.cmet.2010.11.015. Cell Metab. 2010. PMID: 21109198 Free article.

3

SIRT3 reverses aging-associated degeneration.

Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, Zhang D, Scadden DT, Chen D. Brown K, et al. Among authors: chen d. Cell Rep. 2013 Feb 21;3(2):319-27. doi: 10.1016/j.celrep.2013.01.005. Epub 2013 Jan 31. Cell Rep. 2013. PMID: 23375372 Free PMC article.

4

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. Shin J, et al. Among authors: chen d. Cell Rep. 2013 Nov 14;5(3):654-665. doi: 10.1016/j.celrep.2013.10.007. Epub 2013 Nov 7. Cell Rep. 2013. PMID: 24210820 Free PMC article.

5

Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.

Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D. Mohrin M, et al. Among authors: chen d. Science. 2015 Mar 20;347(6228):1374-7. doi: 10.1126/science.aaa2361. Science. 2015. PMID: 25792330 Free PMC article.

6

Nutrient Sensing and the Oxidative Stress Response.

Luo H, Chiang HH, Louw M, Susanto A, Chen D. Luo H, et al. Among authors: chen d. Trends Endocrinol Metab. 2017 Jun;28(6):449-460. doi: 10.1016/j.tem.2017.02.008. Epub 2017 Mar 15. Trends Endocrinol Metab. 2017. PMID: 28314502 Free PMC article. Review.

7

Aging: rewiring the circadian clock.

Ohkubo R, Chen D. Ohkubo R, et al. Among authors: chen d. Nat Struct Mol Biol. 2017 Sep 7;24(9):687-688. doi: 10.1038/nsmb.3461. Nat Struct Mol Biol. 2017. PMID: 28880862 Free PMC article.

8

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence.

Mohrin M, Widjaja A, Liu Y, Luo H, Chen D. Mohrin M, et al. Among authors: chen d. Aging Cell. 2018 Jun;17(3):e12756. doi: 10.1111/acel.12756. Epub 2018 Mar 24. Aging Cell. 2018. PMID: 29575576 Free PMC article.

9

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Luo H, Mu WC, Karki R, Chiang HH, Mohrin M, Shin JJ, Ohkubo R, Ito K, Kanneganti TD, Chen D. Luo H, et al. Among authors: chen d. Cell Rep. 2019 Jan 22;26(4):945-954.e4. doi: 10.1016/j.celrep.2018.12.101. Cell Rep. 2019. PMID: 30673616 Free PMC article.

10

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.

Mu WC, Ohkubo R, Widjaja A, Chen D. Mu WC, et al. Among authors: chen d. Mech Ageing Dev. 2020 Jun;188:111254. doi: 10.1016/j.mad.2020.111254. Epub 2020 Apr 25. Mech Ageing Dev. 2020. PMID: 32343979 Free PMC article. Review.

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