Chen CX - Search Results

1

A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis.

Deneault E, Chaineau M, Nicouleau M, Castellanos Montiel MJ, Franco Flores AK, Haghi G, Chen CX, Abdian N, Shlaifer I, Beitel LK, Durcan TM. Deneault E, et al. Among authors: chen cx. Methods. 2022 Jul;203:297-310. doi: 10.1016/j.ymeth.2021.09.002. Epub 2021 Sep 6. Methods. 2022. PMID: 34500068 Free article.

2

Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders.

Han C, Chaineau M, Chen CX, Beitel LK, Durcan TM. Han C, et al. Among authors: chen cx. Front Neurosci. 2018 Feb 6;12:47. doi: 10.3389/fnins.2018.00047. eCollection 2018. Front Neurosci. 2018. PMID: 29467610 Free PMC article. Review.

3

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.

McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA. McLelland GL, et al. Among authors: chen cx. Elife. 2018 Apr 20;7:e32866. doi: 10.7554/eLife.32866. Elife. 2018. PMID: 29676259 Free PMC article.

4

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.

Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS. Laflamme C, et al. Among authors: chen cx. Elife. 2019 Oct 15;8:e48363. doi: 10.7554/eLife.48363. Elife. 2019. PMID: 31612854 Free PMC article.

5

Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures.

Zhang I, Lépine P, Han C, Lacalle-Aurioles M, Chen CX, Haag R, Durcan TM, Maysinger D. Zhang I, et al. Among authors: chen cx. Cells. 2020 Nov 7;9(11):2434. doi: 10.3390/cells9112434. Cells. 2020. PMID: 33171886 Free PMC article.

6

A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types.

Chen CX, Abdian N, Maussion G, Thomas RA, Demirova I, Cai E, Tabatabaei M, Beitel LK, Karamchandani J, Fon EA, Durcan TM. Chen CX, et al. Methods Protoc. 2021 Jul 19;4(3):50. doi: 10.3390/mps4030050. Methods Protoc. 2021. PMID: 34287353 Free PMC article.

7

Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy.

Mohamed NV, Sirois J, Ramamurthy J, Mathur M, Lépine P, Deneault E, Maussion G, Nicouleau M, Chen CX, Abdian N, Soubannier V, Cai E, Nami H, Thomas RA, Wen D, Tabatabaei M, Beitel LK, Singh Dolt K, Karamchandani J, Stratton JA, Kunath T, Fon EA, Durcan TM. Mohamed NV, et al. Among authors: chen cx. Brain Commun. 2021 Sep 25;3(4):fcab223. doi: 10.1093/braincomms/fcab223. eCollection 2021. Brain Commun. 2021. PMID: 34632384 Free PMC article.

8

Auto-qPCR; a python-based web app for automated and reproducible analysis of qPCR data.

Maussion G, Thomas RA, Demirova I, Gu G, Cai E, Chen CX, Abdian N, Strauss TJP, Kelaï S, Nauleau-Javaudin A, Beitel LK, Ramoz N, Gorwood P, Durcan TM. Maussion G, et al. Among authors: chen cx. Sci Rep. 2021 Oct 29;11(1):21293. doi: 10.1038/s41598-021-99727-6. Sci Rep. 2021. PMID: 34716395 Free PMC article.

9

An approach to measuring protein turnover in human induced pluripotent stem cell organoids by mass spectrometry.

Dong J, Duchesne A, Bayne AN, Mohamed NV, Yi W, Mathur M, Chen CXQ, You Z, Abdian N, Taylor L, Fon EA, Durcan TM, Trempe JF. Dong J, et al. Methods. 2022 Jul;203:17-27. doi: 10.1016/j.ymeth.2022.03.011. Epub 2022 Mar 21. Methods. 2022. PMID: 35331912

10

Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing.

Chen CX, You Z, Abdian N, Sirois J, Shlaifer I, Tabatabaei M, Boivin MN, Gaborieau L, Karamchandani J, Beitel LK, Fon EA, Durcan TM. Chen CX, et al. Stem Cell Res. 2022 Jul;62:102806. doi: 10.1016/j.scr.2022.102806. Epub 2022 May 4. Stem Cell Res. 2022. PMID: 35561458 Free article.

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