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Anchor-based classification and type-C inhibitors for tyrosine kinases.
Hsu KC, Sung TY, Lin CT, Chiu YY, Hsu JT, Hung HC, Sun CM, Barve I, Chen WL, Huang WC, Huang CT, Chen CH, Yang JM. Hsu KC, et al. Among authors: chen wl, chen ch. Sci Rep. 2015 Jun 16;5:10938. doi: 10.1038/srep10938. Sci Rep. 2015. PMID: 26077136 Free PMC article.
Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.
Wu CH, Coumar MS, Chu CY, Lin WH, Chen YR, Chen CT, Shiao HY, Rafi S, Wang SY, Hsu H, Chen CH, Chang CY, Chang TY, Lien TW, Fang MY, Yeh KC, Chen CP, Yeh TK, Hsieh SH, Hsu JT, Liao CC, Chao YS, Hsieh HP. Wu CH, et al. Among authors: chen ct, chen ch, chen yr, chen cp. J Med Chem. 2010 Oct 28;53(20):7316-26. doi: 10.1021/jm100607r. J Med Chem. 2010. PMID: 20961149
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Lin WH, Hsu JT, Hsieh SY, Chen CT, Song JS, Yen SC, Hsu T, Lu CT, Chen CH, Chou LH, Yang YN, Chiu CH, Chen CP, Tseng YJ, Yen KJ, Yeh CF, Chao YS, Yeh TK, Jiaang WT. Lin WH, et al. Among authors: chen ct, chen ch, chen cp. Bioorg Med Chem. 2013 Jun 1;21(11):2856-67. doi: 10.1016/j.bmc.2013.03.083. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23618709
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.
Shiao HY, Coumar MS, Chang CW, Ke YY, Chi YH, Chu CY, Sun HY, Chen CH, Lin WH, Fung KS, Kuo PC, Huang CT, Chang KY, Lu CT, Hsu JT, Chen CT, Jiaang WT, Chao YS, Hsieh HP. Shiao HY, et al. Among authors: chen ct, chen ch. J Med Chem. 2013 Jul 11;56(13):5247-60. doi: 10.1021/jm4006059. Epub 2013 Jun 28. J Med Chem. 2013. PMID: 23808327
8,791 results