Chen CH - Search Results

1

Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.

Chang Hsu Y, Ke YY, Shiao HY, Lee CC, Lin WH, Chen CH, Yen KJ, Hsu JT, Chang C, Hsieh HP. Chang Hsu Y, et al. Among authors: chen ch. ChemMedChem. 2014 May;9(5):953-61. doi: 10.1002/cmdc.201300571. Epub 2014 Mar 24. ChemMedChem. 2014. PMID: 24665000

2

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.

Coumar MS, Leou JS, Shukla P, Wu JS, Dixit AK, Lin WH, Chang CY, Lien TW, Tan UK, Chen CH, Hsu JT, Chao YS, Wu SY, Hsieh HP. Coumar MS, et al. Among authors: chen ch. J Med Chem. 2009 Feb 26;52(4):1050-62. doi: 10.1021/jm801270e. J Med Chem. 2009. PMID: 19140666

3

Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor.

Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP. Coumar MS, et al. Among authors: chen ch. ChemMedChem. 2010 Feb 1;5(2):255-67. doi: 10.1002/cmdc.200900339. ChemMedChem. 2010. PMID: 20039358

4

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Coumar MS, Chu CY, Lin CW, Shiao HY, Ho YL, Reddy R, Lin WH, Chen CH, Peng YH, Leou JS, Lien TW, Huang CT, Fang MY, Wu SH, Wu JS, Chittimalla SK, Song JS, Hsu JT, Wu SY, Liao CC, Chao YS, Hsieh HP. Coumar MS, et al. Among authors: chen ch. J Med Chem. 2010 Jul 8;53(13):4980-8. doi: 10.1021/jm1000198. J Med Chem. 2010. PMID: 20550212

5

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Wu CH, Coumar MS, Chu CY, Lin WH, Chen YR, Chen CT, Shiao HY, Rafi S, Wang SY, Hsu H, Chen CH, Chang CY, Chang TY, Lien TW, Fang MY, Yeh KC, Chen CP, Yeh TK, Hsieh SH, Hsu JT, Liao CC, Chao YS, Hsieh HP. Wu CH, et al. Among authors: chen ct, chen ch, chen yr, chen cp. J Med Chem. 2010 Oct 28;53(20):7316-26. doi: 10.1021/jm100607r. J Med Chem. 2010. PMID: 20961149

6

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

Lin WH, Song JS, Lien TW, Chang CY, Wu SH, Huang YW, Chang TY, Fang MY, Yen KJ, Chen CH, Chu CY, Hsieh HP, Chen YR, Chao YS, Hsu JT. Lin WH, et al. Among authors: chen ch, chen yr. Anticancer Res. 2012 Jan;32(1):147-51. Anticancer Res. 2012. PMID: 22213300

7

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Hsu JT, Yeh TK, Yen SC, Chen CT, Hsieh SY, Hsu T, Lu CT, Chen CH, Chou LH, Chiu CH, Chang YI, Tseng YJ, Yen KR, Chao YS, Lin WH, Jiaang WT. Hsu JT, et al. Among authors: chen ct, chen ch. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4654-9. doi: 10.1016/j.bmcl.2012.05.116. Epub 2012 Jun 7. Bioorg Med Chem Lett. 2012. PMID: 22726931

8

3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.

Ke YY, Shiao HY, Hsu YC, Chu CY, Wang WC, Lee YC, Lin WH, Chen CH, Hsu JT, Chang CW, Lin CW, Yeh TK, Chao YS, Coumar MS, Hsieh HP. Ke YY, et al. Among authors: chen ch. ChemMedChem. 2013 Jan;8(1):136-48. doi: 10.1002/cmdc.201200464. Epub 2012 Nov 22. ChemMedChem. 2013. PMID: 23172777

9

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.

Peng YH, Shiao HY, Tu CH, Liu PM, Hsu JT, Amancha PK, Wu JS, Coumar MS, Chen CH, Wang SY, Lin WH, Sun HY, Chao YS, Lyu PC, Hsieh HP, Wu SY. Peng YH, et al. Among authors: chen ch. J Med Chem. 2013 May 23;56(10):3889-903. doi: 10.1021/jm400072p. Epub 2013 May 10. J Med Chem. 2013. PMID: 23611691

10

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Lin WH, Hsu JT, Hsieh SY, Chen CT, Song JS, Yen SC, Hsu T, Lu CT, Chen CH, Chou LH, Yang YN, Chiu CH, Chen CP, Tseng YJ, Yen KJ, Yeh CF, Chao YS, Yeh TK, Jiaang WT. Lin WH, et al. Among authors: chen ct, chen ch, chen cp. Bioorg Med Chem. 2013 Jun 1;21(11):2856-67. doi: 10.1016/j.bmc.2013.03.083. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23618709

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