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Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Netcharoensirisuk P, Abrahamian C, Tang R, Chen CC, Rosato AS, Beyers W, Chao YK, Filippini A, Di Pietro S, Bartel K, Biel M, Vollmar AM, Umehara K, De-Eknamkul W, Grimm C. Netcharoensirisuk P, et al. Among authors: chen cc. Sci Rep. 2021 Apr 19;11(1):8515. doi: 10.1038/s41598-021-88196-6. Sci Rep. 2021. PMID: 33875769 Free PMC article.
Cellular zinc levels are modulated by TRPML1-TMEM163 interaction.
Cuajungco MP, Basilio LC, Silva J, Hart T, Tringali J, Chen CC, Biel M, Grimm C. Cuajungco MP, et al. Among authors: chen cc. Traffic. 2014 Nov;15(11):1247-65. doi: 10.1111/tra.12205. Epub 2014 Sep 2. Traffic. 2014. PMID: 25130899 Free PMC article.
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C. Grimm C, et al. Among authors: chen cc. Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699. Nat Commun. 2014. PMID: 25144390 Free article.
6,979 results