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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF.
Decaris ML, Schaub JR, Chen C, Cha J, Lee GG, Rexhepaj M, Ho SS, Rao V, Marlow MM, Kotak P, Budi EH, Hooi L, Wu J, Fridlib M, Martin SP, Huang S, Chen M, Muñoz M, Hom TF, Wolters PJ, Desai TJ, Rock F, Leftheris K, Morgans DJ, Lepist EI, Andre P, Lefebvre EA, Turner SM. Decaris ML, et al. Among authors: chen m, chen c. Respir Res. 2021 Oct 19;22(1):265. doi: 10.1186/s12931-021-01863-0. Respir Res. 2021. PMID: 34666752 Free PMC article.
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Sundaram A, et al. Among authors: chen c. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127578. doi: 10.1016/j.bmcl.2020.127578. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007395 Free PMC article.
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: chen c. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.
De novo revertant fiber formation and therapy testing in a 3D culture model of Duchenne muscular dystrophy skeletal muscle.
Ebrahimi M, Lad H, Fusto A, Tiper Y, Datye A, Nguyen CT, Jacques E, Moyle LA, Nguyen T, Musgrave B, Chávez-Madero C, Bigot A, Chen C, Turner S, Stewart BA, Pegoraro E, Vitiello L, Gilbert PM. Ebrahimi M, et al. Among authors: chen c. Acta Biomater. 2021 Sep 15;132:227-244. doi: 10.1016/j.actbio.2021.05.020. Epub 2021 May 25. Acta Biomater. 2021. PMID: 34048976
86,208 results
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