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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Schulze CJ, Seamon KJ, Zhao Y, Yang YC, Cregg J, Kim D, Tomlinson A, Choy TJ, Wang Z, Sang B, Pourfarjam Y, Lucas J, Cuevas-Navarro A, Ayala-Santos C, Vides A, Li C, Marquez A, Zhong M, Vemulapalli V, Weller C, Gould A, Whalen DM, Salvador A, Milin A, Saldajeno-Concar M, Dinglasan N, Chen A, Evans J, Knox JE, Koltun ES, Singh M, Nichols R, Wildes D, Gill AL, Smith JAM, Lito P. Schulze CJ, et al. Among authors: chen a. Science. 2023 Aug 18;381(6659):794-799. doi: 10.1126/science.adg9652. Epub 2023 Aug 17. Science. 2023. PMID: 37590355 Free PMC article.
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Holderfield M, Lee BJ, Jiang J, Tomlinson A, Seamon KJ, Mira A, Patrucco E, Goodhart G, Dilly J, Gindin Y, Dinglasan N, Wang Y, Lai LP, Cai S, Jiang L, Nasholm N, Shifrin N, Blaj C, Shah H, Evans JW, Montazer N, Lai O, Shi J, Ahler E, Quintana E, Chang S, Salvador A, Marquez A, Cregg J, Liu Y, Milin A, Chen A, Ziv TB, Parsons D, Knox JE, Klomp JE, Roth J, Rees M, Ronan M, Cuevas-Navarro A, Hu F, Lito P, Santamaria D, Aguirre AJ, Waters AM, Der CJ, Ambrogio C, Wang Z, Gill AL, Koltun ES, Smith JAM, Wildes D, Singh M. Holderfield M, et al. Among authors: chen a. Nature. 2024 Apr 8. doi: 10.1038/s41586-024-07205-6. Online ahead of print. Nature. 2024. PMID: 38589574
Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody.
Chang YH, Hsu MF, Chen WN, Wu MH, Kong WL, Lu MJ, Huang CH, Chang FJ, Chang LY, Tsai HY, Tung CP, Yu JH, Kuo Y, Chou YC, Bai LY, Chang YC, Chen AY, Chen CC, Chen YH, Liao CC, Chang CS, Liang JJ, Lin YL, Angata T, Hsu SD, Lin KI. Chang YH, et al. Among authors: chen ay. JCI Insight. 2024 May 22;9(10):e179726. doi: 10.1172/jci.insight.179726. JCI Insight. 2024. PMID: 38775156
Polysaccharide functionalization reduces lipid vesicle stiffness.
Jahnke K, Pavlovic M, Xu W, Chen A, Knowles TPJ, Arriaga LR, Weitz DA. Jahnke K, et al. Among authors: chen a. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2317227121. doi: 10.1073/pnas.2317227121. Epub 2024 May 21. Proc Natl Acad Sci U S A. 2024. PMID: 38771870
Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals.
Mi X, Chen AB, Duarte D, Carey E, Taylor CR, Braaker PN, Bright M, Almeida RG, Lim JX, Rutten VM, Zheng W, Wang M, Reitman ME, Wang Y, Poskanzer KE, Lyons DA, Nimmerjahn A, Ahrens MB, Yu G. Mi X, et al. Among authors: chen ab. bioRxiv [Preprint]. 2024 May 6:2024.05.02.592259. doi: 10.1101/2024.05.02.592259. bioRxiv. 2024. PMID: 38766026 Free PMC article. Preprint.
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