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A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo.
Suchowerska AK, Stokman G, Palmer JT, Coghlan PA, Pieterman EJ, Keijzer N, Lambert G, Chemello K, Jaafar AK, Parmar J, Yan L, Tong Y, Mu L, Princen HMG, Bonnar J, Evison BJ. Suchowerska AK, et al. Among authors: chemello k. J Lipid Res. 2022 Nov;63(11):100293. doi: 10.1016/j.jlr.2022.100293. Epub 2022 Oct 6. J Lipid Res. 2022. PMID: 36209894 Free PMC article.
Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study.
Blanchard V, Ramin-Mangata S, Billon-Crossouard S, Aguesse A, Durand M, Chemello K, Nativel B, Flet L, Chétiveaux M, Jacobi D, Bard JM, Ouguerram K, Lambert G, Krempf M, Croyal M. Blanchard V, et al. Among authors: chemello k. J Lipid Res. 2018 May;59(5):892-900. doi: 10.1194/jlr.P083576. Epub 2018 Mar 14. J Lipid Res. 2018. PMID: 29540575 Free PMC article.
PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate.
Croyal M, Tran TT, Blanchard RH, Le Bail JC, Villard EF, Poirier B, Aguesse A, Billon-Crossouard S, Ramin-Mangata S, Blanchard V, Nativel B, Chemello K, Khantalin I, Thedrez A, Janiak P, Krempf M, Boixel C, Lambert G, Guillot E. Croyal M, et al. Among authors: chemello k. Clin Sci (Lond). 2018 May 31;132(10):1075-1083. doi: 10.1042/CS20180040. Print 2018 May 31. Clin Sci (Lond). 2018. PMID: 29724769
PCSK9: from biology to clinical applications.
Blanchard V, Khantalin I, Ramin-Mangata S, Chémello K, Nativel B, Lambert G. Blanchard V, et al. Among authors: chemello k. Pathology. 2019 Feb;51(2):177-183. doi: 10.1016/j.pathol.2018.10.012. Epub 2018 Dec 4. Pathology. 2019. PMID: 30522786 Review.
PCSK9 inhibition for autosomal recessive hypercholesterolemia.
Chemello K, Martín C, Lambert G. Chemello K, et al. Atherosclerosis. 2019 May;284:209-211. doi: 10.1016/j.atherosclerosis.2019.02.013. Epub 2019 Feb 23. Atherosclerosis. 2019. PMID: 30862376 No abstract available.
A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove.
Evison BJ, Palmer JT, Lambert G, Treutlein H, Zeng J, Nativel B, Chemello K, Zhu Q, Wang J, Teng Y, Tang W, Xu Y, Rathi AK, Kumar S, Suchowerska AK, Parmar J, Dixon I, Kelly GE, Bonnar J. Evison BJ, et al. Among authors: chemello k. Bioorg Med Chem. 2020 Mar 15;28(6):115344. doi: 10.1016/j.bmc.2020.115344. Epub 2020 Jan 31. Bioorg Med Chem. 2020. PMID: 32051094 Free article.
A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins.
Blanchard V, Garçon D, Jaunet C, Chemello K, Billon-Crossouard S, Aguesse A, Garfa A, Famchon G, Torres A, Le May C, Pichelin M, Bigot-Corbel E, Lambert G, Cariou B, Hadjadj S, Krempf M, Bach-Ngohou K, Croyal M. Blanchard V, et al. Among authors: chemello k. J Lipid Res. 2020 Jul;61(7):1128-1139. doi: 10.1194/jlr.D120000835. Epub 2020 May 13. J Lipid Res. 2020. PMID: 32404332 Free PMC article.
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab.
Chemello K, Beeské S, Trang Tran TT, Blanchard V, Villard EF, Poirier B, Le Bail JC, Dargazanli G, Ho-Van-Guimbal S, Boulay D, Bergis O, Pruniaux MP, Croyal M, Janiak P, Guillot E, Lambert G. Chemello K, et al. JACC Basic Transl Sci. 2020 May 6;5(6):549-557. doi: 10.1016/j.jacbts.2020.03.008. eCollection 2020 Jun. JACC Basic Transl Sci. 2020. PMID: 32613143 Free PMC article.
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Huijgen R, Blom DJ, Hartgers ML, Chemello K, Benito-Vicente A, Uribe KB, Behardien Z, Blackhurst DM, Brice BC, Defesche JC, de Jong AG, Jooste RJ, Solomon GAE, Wolmarans KH, Hovingh GK, Martin C, Lambert G, Marais AD. Huijgen R, et al. Among authors: chemello k. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):934-943. doi: 10.1161/ATVBAHA.120.314482. Epub 2020 Nov 5. Arterioscler Thromb Vasc Biol. 2021. PMID: 33147992 Free article.
Lipoprotein metabolism in familial hypercholesterolemia.
Chemello K, García-Nafría J, Gallo A, Martín C, Lambert G, Blom D. Chemello K, et al. J Lipid Res. 2021;62:100062. doi: 10.1016/j.jlr.2021.100062. Epub 2021 Mar 3. J Lipid Res. 2021. PMID: 33675717 Free PMC article. Review.
24 results