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Tetracycline repurposing in neurodegeneration: focus on Parkinson's disease.
Bortolanza M, Nascimento GC, Socias SB, Ploper D, Chehín RN, Raisman-Vozari R, Del-Bel E. Bortolanza M, et al. Among authors: chehin rn. J Neural Transm (Vienna). 2018 Oct;125(10):1403-1415. doi: 10.1007/s00702-018-1913-1. Epub 2018 Aug 14. J Neural Transm (Vienna). 2018. PMID: 30109452 Review.
Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation.
Torres-Bugeau CM, Ávila CL, Raisman-Vozari R, Papy-Garcia D, Itri R, Barbosa LR, Cortez LM, Sim VL, Chehín RN. Torres-Bugeau CM, et al. Among authors: chehin rn. J Biol Chem. 2012 Jan 20;287(4):2398-409. doi: 10.1074/jbc.M111.303503. Epub 2011 Dec 1. J Biol Chem. 2012. PMID: 22134915 Free PMC article.
Structural characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase protofibrils preventing α-synuclein oligomeric species toxicity.
Ávila CL, Torres-Bugeau CM, Barbosa LR, Sales EM, Ouidja MO, Socías SB, Celej MS, Raisman-Vozari R, Papy-Garcia D, Itri R, Chehín RN. Ávila CL, et al. Among authors: chehin rn. J Biol Chem. 2014 May 16;289(20):13838-50. doi: 10.1074/jbc.M113.544288. Epub 2014 Mar 26. J Biol Chem. 2014. PMID: 24671416 Free PMC article.
Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species.
González-Lizárraga F, Socías SB, Ávila CL, Torres-Bugeau CM, Barbosa LR, Binolfi A, Sepúlveda-Díaz JE, Del-Bel E, Fernandez CO, Papy-Garcia D, Itri R, Raisman-Vozari R, Chehín RN. González-Lizárraga F, et al. Among authors: chehin rn. Sci Rep. 2017 Feb 3;7:41755. doi: 10.1038/srep41755. Sci Rep. 2017. PMID: 28155912 Free PMC article.
Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates.
Acuña L, Hamadat S, Corbalán NS, González-Lizárraga F, Dos-Santos-Pereira M, Rocca J, Díaz JS, Del-Bel E, Papy-García D, Chehín RN, Michel PP, Raisman-Vozari R. Acuña L, et al. Among authors: chehin rn. Cells. 2019 Jul 25;8(8):776. doi: 10.3390/cells8080776. Cells. 2019. PMID: 31349736 Free PMC article.
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo.
Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF. Dominguez-Meijide A, et al. Neurobiol Dis. 2021 Apr;151:105256. doi: 10.1016/j.nbd.2021.105256. Epub 2021 Jan 8. Neurobiol Dis. 2021. PMID: 33429042 Free article.
41 results