6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.
Alves da Costa C, Dunys J, Brau F, Wilk S, Cappai R, Checler F.
Alves da Costa C, et al. Among authors: checler f.
J Biol Chem. 2006 Apr 7;281(14):9824-31. doi: 10.1074/jbc.M513903200. Epub 2006 Feb 7.
J Biol Chem. 2006.
PMID: 16464850
Free article.
We established previously that alpha-synuclein displayed a protective anti-apoptotic phenotype in neurons, mainly by down-regulating p53-dependent caspase-3 activation (Alves da Costa, C., Ancolio, K., and Checler, F. (2000) J. Biol. Chem. 275, 24065-24069; Alves da …
We established previously that alpha-synuclein displayed a protective anti-apoptotic phenotype in neurons, mainly by down-regulating p53-dep …