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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG. Benjannet S, et al. Among authors: checler f. J Biol Chem. 2001 Apr 6;276(14):10879-87. doi: 10.1074/jbc.M009899200. Epub 2001 Jan 10. J Biol Chem. 2001. PMID: 11152688 Free article.
BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
Andrau D, Dumanchin-Njock C, Ayral E, Vizzavona J, Farzan M, Boisbrun M, Fulcrand P, Hernandez JF, Martinez J, Lefranc-Jullien S, Checler F. Andrau D, et al. Among authors: checler f. J Biol Chem. 2003 Jul 11;278(28):25859-66. doi: 10.1074/jbc.M302622200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736275 Free article.
6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.
Alves da Costa C, Dunys J, Brau F, Wilk S, Cappai R, Checler F. Alves da Costa C, et al. Among authors: checler f. J Biol Chem. 2006 Apr 7;281(14):9824-31. doi: 10.1074/jbc.M513903200. Epub 2006 Feb 7. J Biol Chem. 2006. PMID: 16464850 Free article.
We established previously that alpha-synuclein displayed a protective anti-apoptotic phenotype in neurons, mainly by down-regulating p53-dependent caspase-3 activation (Alves da Costa, C., Ancolio, K., and Checler, F. (2000) J. Biol. Chem. 275, 24065-24069; Alves da …
We established previously that alpha-synuclein displayed a protective anti-apoptotic phenotype in neurons, mainly by down-regulating p53-dep …
275 results