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Page 1
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health.
Townsend L, Dyer AH, Naughton A, Kiersey R, Holden D, Gardiner M, Dowds J, O'Brien K, Bannan C, Nadarajan P, Dunne J, Martin-Loeches I, Fallon PG, Bergin C, O'Farrelly C, Cheallaigh CN, Bourke NM, Conlon N. Townsend L, et al. Among authors: cheallaigh cn. Front Immunol. 2021 May 7;12:676932. doi: 10.3389/fimmu.2021.676932. eCollection 2021. Front Immunol. 2021. PMID: 34025675 Free PMC article.
Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.
Pelleau S, Woudenberg T, Rosado J, Donnadieu F, Garcia L, Obadia T, Gardais S, Elgharbawy Y, Velay A, Gonzalez M, Nizou JY, Khelil N, Zannis K, Cockram C, Merkling SH, Meola A, Kerneis S, Terrier B, de Seze J, Planas D, Schwartz O, Dejardin F, Petres S, von Platen C, Pellerin SF, Arowas L, de Facci LP, Duffy D, Cheallaigh CN, Dunne J, Conlon N, Townsend L, Duong V, Auerswald H, Pinaud L, Tondeur L, Backovic M, Hoen B, Fontanet A, Mueller I, Fafi-Kremer S, Bruel T, White M. Pelleau S, et al. Among authors: cheallaigh cn. J Infect Dis. 2021 Nov 16;224(9):1489-1499. doi: 10.1093/infdis/jiab375. J Infect Dis. 2021. PMID: 34282461 Free PMC article.
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY,… See abstract for full author list ➔ Bastard P, et al. Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340. Sci Immunol. 2021. PMID: 34413139 Free PMC article.
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression.
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Hennessy M, Byrne D, Browne P, Bacon CL, Doyle C, O'Riordan R, McLaughlin AM, Bannan C, Martin-Loeches I, White A, McLoughlin RM, Bergin C, Bourke NM, O'Farrelly C, Conlon N, Cheallaigh CN; STAR COVID Bioresource. Townsend L, et al. Among authors: cheallaigh cn. Heliyon. 2022 Apr;8(4):e09230. doi: 10.1016/j.heliyon.2022.e09230. Epub 2022 Apr 1. Heliyon. 2022. PMID: 35386227 Free PMC article.
Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction.
Fogarty H, Ward SE, Townsend L, Karampini E, Elliott S, Conlon N, Dunne J, Kiersey R, Naughton A, Gardiner M, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, Baker RI, Cheallaigh CN, O'Donnell JS; Irish COVID-19 Vasculopathy Study (iCVS) Investigators. Fogarty H, et al. Among authors: cheallaigh cn. J Thromb Haemost. 2022 Oct;20(10):2429-2438. doi: 10.1111/jth.15830. Epub 2022 Aug 4. J Thromb Haemost. 2022. PMID: 35875995 Free PMC article.
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.
Smith N, Possémé C, Bondet V, Sugrue J, Townsend L, Charbit B, Rouilly V, Saint-André V, Dott T, Pozo AR, Yatim N, Schwartz O, Cervantes-Gonzalez M, Ghosn J, Bastard P, Casanova JL, Szwebel TA, Terrier B, Conlon N, O'Farrelly C, Cheallaigh CN, Bourke NM, Duffy D. Smith N, et al. Among authors: cheallaigh cn. Nat Commun. 2022 Nov 25;13(1):7254. doi: 10.1038/s41467-022-34895-1. Nat Commun. 2022. PMID: 36434007 Free PMC article.
Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19.
Karampini E, Fogarty H, Elliott S, Morrin H, Bergin C, O'Sullivan JM, Byrne M, Martin-Loeches I, Mallon PW, Curley GF, Glavey S, Baker RI, Lavin M, Preston RJS, Cheallaigh CN, Ward SE, O'Donnell JS. Karampini E, et al. Among authors: cheallaigh cn. Res Pract Thromb Haemost. 2023 Feb;7(2):100085. doi: 10.1016/j.rpth.2023.100085. Epub 2023 Feb 14. Res Pract Thromb Haemost. 2023. PMID: 36817284 Free PMC article.
Characterisation of the pro-inflammatory cytokine signature in severe COVID-19.
Hawerkamp HC, Dyer AH, Patil ND, McElheron M, O'Dowd N, O'Doherty L, Mhaonaigh AU, George AM, O'Halloran AM, Reddy C, Kenny RA, Little MA, Martin-Loeches I, Bergin C, Kennelly SP, Donnelly SC, Bourke NM, Long A, Sui J, Doherty DG, Conlon N, Cheallaigh CN, Fallon PG. Hawerkamp HC, et al. Among authors: cheallaigh cn. Front Immunol. 2023 Mar 30;14:1170012. doi: 10.3389/fimmu.2023.1170012. eCollection 2023. Front Immunol. 2023. PMID: 37063871 Free PMC article.
22 results