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A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice.
Brabant M, Baux L, Casimir R, Briand JP, Chaloin O, Porceddu M, Buron N, Chauvier D, Lassalle M, Lecoeur H, Langonné A, Dupont S, Déas O, Brenner C, Rebouillat D, Muller S, Borgne-Sanchez A, Jacotot E. Brabant M, et al. Among authors: chauvier d. Apoptosis. 2009 Oct;14(10):1190-203. doi: 10.1007/s10495-009-0394-y. Apoptosis. 2009. PMID: 19693674
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells.
Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E. Borgne-Sanchez A, et al. Among authors: chauvier d. Cell Death Differ. 2007 Mar;14(3):422-35. doi: 10.1038/sj.cdd.4402018. Epub 2006 Aug 4. Cell Death Differ. 2007. PMID: 16888644
Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.
Chauvier D, Renolleau S, Holifanjaniaina S, Ankri S, Bezault M, Schwendimann L, Rousset C, Casimir R, Hoebeke J, Smirnova M, Debret G, Trichet AP, Carlsson Y, Wang X, Bernard E, Hébert M, Rauzier JM, Matecki S, Lacampagne A, Rustin P, Mariani J, Hagberg H, Gressens P, Charriaut-Marlangue C, Jacotot E. Chauvier D, et al. Cell Death Dis. 2011 Sep 1;2(9):e203. doi: 10.1038/cddis.2011.87. Cell Death Dis. 2011. PMID: 21881605 Free PMC article.
Broad-spectrum caspase inhibitors: from myth to reality?
Chauvier D, Ankri S, Charriaut-Marlangue C, Casimir R, Jacotot E. Chauvier D, et al. Cell Death Differ. 2007 Feb;14(2):387-91. doi: 10.1038/sj.cdd.4402044. Epub 2006 Sep 29. Cell Death Differ. 2007. PMID: 17008913 No abstract available.
Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion.
Fauconnier J, Meli AC, Thireau J, Roberge S, Shan J, Sassi Y, Reiken SR, Rauzier JM, Marchand A, Chauvier D, Cassan C, Crozier C, Bideaux P, Lompré AM, Jacotot E, Marks AR, Lacampagne A. Fauconnier J, et al. Among authors: chauvier d. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13258-63. doi: 10.1073/pnas.1100286108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788490 Free PMC article.
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