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Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.
Lanning ME, Yu W, Yap JL, Chauhan J, Chen L, Whiting E, Pidugu LS, Atkinson T, Bailey H, Li W, Roth BM, Hynicka L, Chesko K, Toth EA, Shapiro P, MacKerell AD Jr, Wilder PT, Fletcher S. Lanning ME, et al. Among authors: chauhan j. Eur J Med Chem. 2016 May 4;113:273-92. doi: 10.1016/j.ejmech.2016.02.006. Epub 2016 Feb 4. Eur J Med Chem. 2016. PMID: 26985630 Free PMC article.
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher S. Yap JL, et al. Among authors: chauhan j. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2013. PMID: 23177256 Free PMC article.
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
Jung KY, Samadani R, Chauhan J, Nevels K, Yap JL, Zhang J, Worlikar S, Lanning ME, Chen L, Ensey M, Shukla S, Salmo R, Heinzl G, Gordon C, Dukes T, MacKerell AD Jr, Shapiro P, Fletcher S. Jung KY, et al. Among authors: chauhan j. Org Biomol Chem. 2013 Jun 14;11(22):3706-32. doi: 10.1039/c3ob40199e. Org Biomol Chem. 2013. PMID: 23624850 Free PMC article.
Structure-activity exploration of a small-molecule Lipid II inhibitor.
Fletcher S, Yu W, Huang J, Kwasny SM, Chauhan J, Opperman TJ, MacKerell AD Jr, de Leeuw E. Fletcher S, et al. Among authors: chauhan j. Drug Des Devel Ther. 2015 Apr 24;9:2383-94. doi: 10.2147/DDDT.S79504. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25987836 Free PMC article.
Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold.
Whiting E, Raje MR, Chauhan J, Wilder PT, Van Eker D, Hughes SJ, Bowen NG, Vickers GEA, Fenimore IC, Fletcher S. Whiting E, et al. Among authors: chauhan j. Bioorg Med Chem Lett. 2018 Feb 1;28(3):523-528. doi: 10.1016/j.bmcl.2017.11.023. Epub 2017 Dec 12. Bioorg Med Chem Lett. 2018. PMID: 29329659
Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors.
Conlon IL, Van Eker D, Abdelmalak S, Murphy WA, Bashir H, Sun M, Chauhan J, Varney KM, Godoy-Ruiz R, Wilder PT, Fletcher S. Conlon IL, et al. Among authors: chauhan j. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1949-1953. doi: 10.1016/j.bmcl.2018.03.050. Epub 2018 Mar 26. Bioorg Med Chem Lett. 2018. PMID: 29705141
225 results