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Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. Hartmann J, et al. Among authors: chatzinakos c. Cell Rep. 2021 Jun 1;35(9):109185. doi: 10.1016/j.celrep.2021.109185. Cell Rep. 2021. PMID: 34077736 Free PMC article.
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.
Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH; PTSD Working Group of Psychiatric Genomics Consortium; Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Huckins LM, et al. Among authors: chatzinakos c. Cell Rep. 2020 Jun 2;31(9):107716. doi: 10.1016/j.celrep.2020.107716. Cell Rep. 2020. PMID: 32492425 Free PMC article.
Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.
Chatzinakos C, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. Chatzinakos C, et al. Am J Med Genet B Neuropsychiatr Genet. 2021 Jan;186(1):16-27. doi: 10.1002/ajmg.b.32834. Epub 2021 Feb 11. Am J Med Genet B Neuropsychiatr Genet. 2021. PMID: 33576176 Free PMC article. Review.
From genetics to systems biology of stress-related mental disorders.
Dalvie S, Chatzinakos C, Al Zoubi O, Georgiadis F; PGC-PTSD Systems Biology workgroup; Lancashire L, Daskalakis NP. Dalvie S, et al. Among authors: chatzinakos c. Neurobiol Stress. 2021 Sep 12;15:100393. doi: 10.1016/j.ynstr.2021.100393. eCollection 2021 Nov. Neurobiol Stress. 2021. PMID: 34584908 Free PMC article.
Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes.
Bountress KE, Bustamante D, Subbie-Saenz de Viteri S, Chatzinakos C, Sheerin C, Daskalakis NP, Edenberg HJ; Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group; Peterson RE, Webb BT, Meyers J, Amstadter A. Bountress KE, et al. Among authors: chatzinakos c. Psychol Med. 2023 Sep;53(12):5767-5777. doi: 10.1017/S0033291722002999. Epub 2022 Sep 30. Psychol Med. 2023. PMID: 36177877
TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders.
Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. Chatzinakos C, et al. Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):454-463. doi: 10.1002/ajmg.b.32823. Epub 2020 Sep 21. Am J Med Genet B Neuropsychiatr Genet. 2020. PMID: 32954640 Free PMC article.
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