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Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD. Zhang P, et al. Among authors: chatterjee ak. J Am Chem Soc. 2021 Aug 25;143(33):13044-13055. doi: 10.1021/jacs.1c02248. Epub 2021 Aug 13. J Am Chem Soc. 2021. PMID: 34387474 Free PMC article.
Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.
Choi SH, Mahankali M, Lee SJ, Hull M, Petrassi HM, Chatterjee AK, Schultz PG, Jones KA, Shen W. Choi SH, et al. Among authors: chatterjee ak. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. doi: 10.1021/acschembio.7b00799. Epub 2017 Oct 11. ACS Chem Biol. 2017. PMID: 28976731
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.
Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD. Velagapudi SP, et al. Among authors: chatterjee ak. Cell Chem Biol. 2018 Sep 20;25(9):1086-1094.e7. doi: 10.1016/j.chembiol.2018.05.015. Epub 2018 Jun 28. Cell Chem Biol. 2018. PMID: 30251629 Free PMC article.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
Zambaldo C, Vinogradova EV, Qi X, Iaconelli J, Suciu RM, Koh M, Senkane K, Chadwick SR, Sanchez BB, Chen JS, Chatterjee AK, Liu P, Schultz PG, Cravatt BF, Bollong MJ. Zambaldo C, et al. Among authors: chatterjee ak. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29. J Am Chem Soc. 2020. PMID: 32302104 Free PMC article.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Shalhout SZ, Yang PY, Grzelak EM, Nutsch K, Shao S, Zambaldo C, Iaconelli J, Ibrahim L, Stanton C, Chadwick SR, Chen E, DeRan M, Li S, Hull M, Wu X, Chatterjee AK, Shen W, Camargo FD, Schultz PG, Bollong MJ. Shalhout SZ, et al. Among authors: chatterjee ak. Nat Chem Biol. 2021 Jul;17(7):767-775. doi: 10.1038/s41589-021-00755-0. Epub 2021 Mar 15. Nat Chem Biol. 2021. PMID: 33723431
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56. doi: 10.1038/nchembio.87. Epub 2008 May 4. Nat Chem Biol. 2008. PMID: 18454143
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnsson K, Mikusova K, Besra GS, Fütterer K, Robbins SH, Barnes SW, Walker JR, Jacobs WR Jr, Schultz PG. Wang F, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. doi: 10.1073/pnas.1309171110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776209 Free PMC article.
Small molecule selectively suppresses MYC transcription in cancer cells.
Bouvard C, Lim SM, Ludka J, Yazdani N, Woods AK, Chatterjee AK, Schultz PG, Zhu S. Bouvard C, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502. doi: 10.1073/pnas.1702663114. Epub 2017 Mar 14. Proc Natl Acad Sci U S A. 2017. PMID: 28292893 Free PMC article.
A small molecule UPR modulator for diabetes identified by high throughput screening.
Marrocco V, Tran T, Zhu S, Choi SH, Gamo AM, Li S, Fu Q, Cunado MD, Roland J, Hull M, Nguyen-Tran V, Joseph S, Chatterjee AK, Rogers N, Tremblay MS, Shen W. Marrocco V, et al. Among authors: chatterjee ak. Acta Pharm Sin B. 2021 Dec;11(12):3983-3993. doi: 10.1016/j.apsb.2021.05.018. Epub 2021 Jun 16. Acta Pharm Sin B. 2021. PMID: 35024320 Free PMC article.
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR 3rd, Becker C, Rogers TF, Chatterjee AK, Lipton SA. Oh CK, et al. Among authors: chatterjee ak. Nat Chem Biol. 2023 Mar;19(3):275-283. doi: 10.1038/s41589-022-01149-6. Epub 2022 Sep 29. Nat Chem Biol. 2023. PMID: 36175661 Free PMC article.
314 results