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Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
Fernández B, Chittoor-Vinod VG, Kluss JH, Kelly K, Bryant N, Nguyen APT, Bukhari SA, Smith N, Lara Ordóñez AJ, Fdez E, Chartier-Harlin MC, Montine TJ, Wilson MA, Moore DJ, West AB, Cookson MR, Nichols RJ, Hilfiker S. Fernández B, et al. Among authors: chartier harlin mc. J Parkinsons Dis. 2022;12(5):1423-1447. doi: 10.3233/JPD-213128. J Parkinsons Dis. 2022. PMID: 35599495 Free PMC article.
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S. Blanca Ramírez M, et al. Hum Mol Genet. 2017 Jul 15;26(14):2747-2767. doi: 10.1093/hmg/ddx161. Hum Mol Genet. 2017. PMID: 28453723 Free PMC article.
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, Pinton P, Greggio E. Civiero L, et al. Front Mol Neurosci. 2017 Dec 14;10:417. doi: 10.3389/fnmol.2017.00417. eCollection 2017. Front Mol Neurosci. 2017. PMID: 29311810 Free PMC article.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S. Madero-Pérez J, et al. Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y. Mol Neurodegener. 2018. PMID: 29357897 Free PMC article.
Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation.
Drouyer M, Bolliger MF, Lobbestael E, Van den Haute C, Emanuele M, Lefebvre R, Sibran W, De Wit T, Leghay C, Mutez E, Dzamko N, Halliday GM, Murayama S, Martoriati A, Cailliau K, Bodart JF, Chartier-Harlin MC, Baekelandt V, Nichols RJ, Taymans JM. Drouyer M, et al. Neurobiol Dis. 2021 Sep;157:105426. doi: 10.1016/j.nbd.2021.105426. Epub 2021 Jun 16. Neurobiol Dis. 2021. PMID: 34144124 Free article.
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Cresto N, Gardier C, Gaillard MC, Gubinelli F, Roost P, Molina D, Josephine C, Dufour N, Auregan G, Guillermier M, Bernier S, Jan C, Gipchtein P, Hantraye P, Chartier-Harlin MC, Bonvento G, Van Camp N, Taymans JM, Cambon K, Liot G, Bemelmans AP, Brouillet E. Cresto N, et al. Int J Mol Sci. 2021 Jun 23;22(13):6760. doi: 10.3390/ijms22136760. Int J Mol Sci. 2021. PMID: 34201785 Free PMC article.
127 results