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Reducing the impact of radioactivity on quantum circuits in a deep-underground facility.
Cardani L, Valenti F, Casali N, Catelani G, Charpentier T, Clemenza M, Colantoni I, Cruciani A, D'Imperio G, Gironi L, Grünhaupt L, Gusenkova D, Henriques F, Lagoin M, Martinez M, Pettinari G, Rusconi C, Sander O, Tomei C, Ustinov AV, Weber M, Wernsdorfer W, Vignati M, Pirro S, Pop IM. Cardani L, et al. Among authors: charpentier t. Nat Commun. 2021 May 12;12(1):2733. doi: 10.1038/s41467-021-23032-z. Nat Commun. 2021. PMID: 33980835 Free PMC article.
The experimental power of FR900359 to study Gq-regulated biological processes.
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. Schrage R, et al. Among authors: charpentier th. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. Nat Commun. 2015. PMID: 26658454 Free PMC article.
A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.
Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E. Schmitz AL, et al. Among authors: charpentier th. Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003. Chem Biol. 2014. PMID: 25036778 Free PMC article.
Potent and Selective Peptide-based Inhibition of the G Protein Gαq.
Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J. Charpentier TH, et al. J Biol Chem. 2016 Dec 2;291(49):25608-25616. doi: 10.1074/jbc.M116.740407. Epub 2016 Oct 14. J Biol Chem. 2016. PMID: 27742837 Free PMC article.
Membrane-induced allosteric control of phospholipase C-β isozymes.
Charpentier TH, Waldo GL, Barrett MO, Huang W, Zhang Q, Harden TK, Sondek J. Charpentier TH, et al. J Biol Chem. 2014 Oct 24;289(43):29545-57. doi: 10.1074/jbc.M114.586784. Epub 2014 Sep 5. J Biol Chem. 2014. PMID: 25193662 Free PMC article.
Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma.
Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL. Lapadula D, et al. Among authors: charpentier th. Mol Cancer Res. 2019 Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19. Mol Cancer Res. 2019. PMID: 30567972 Free PMC article.
Design of Inhibitors for S100B.
Markowitz J, Mackerell AD Jr, Carrier F, Charpentier TH, Weber DJ. Markowitz J, et al. Curr Top Med Chem. 2005;5(12):1093-108. doi: 10.2174/156802605774370865. Curr Top Med Chem. 2005. PMID: 16248785 Review.
115 results