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An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
Burke AJ, Birmingham WR, Zhuo Y, Thorpe TW, Zucoloto da Costa B, Crawshaw R, Rowles I, Finnigan JD, Young C, Holgate GM, Muldowney MP, Charnock SJ, Lovelock SL, Turner NJ, Green AP. Burke AJ, et al. Among authors: charnock sj. J Am Chem Soc. 2022 Mar 9;144(9):3761-3765. doi: 10.1021/jacs.1c11048. Epub 2022 Feb 28. J Am Chem Soc. 2022. PMID: 35224970 Free PMC article.
Multifunctional biocatalyst for conjugate reduction and reductive amination.
Thorpe TW, Marshall JR, Harawa V, Ruscoe RE, Cuetos A, Finnigan JD, Angelastro A, Heath RS, Parmeggiani F, Charnock SJ, Howard RM, Kumar R, Daniels DSB, Grogan G, Turner NJ. Thorpe TW, et al. Among authors: charnock sj. Nature. 2022 Apr;604(7904):86-91. doi: 10.1038/s41586-022-04458-x. Epub 2022 Apr 6. Nature. 2022. PMID: 35388195
53 results