Chari A - Search Results

1

Cryo-EM in drug discovery: achievements, limitations and prospects.

Renaud JP, Chari A, Ciferri C, Liu WT, Rémigy HW, Stark H, Wiesmann C. Renaud JP, et al. Among authors: chari a. Nat Rev Drug Discov. 2018 Jul;17(7):471-492. doi: 10.1038/nrd.2018.77. Epub 2018 Jun 8. Nat Rev Drug Discov. 2018. PMID: 29880918 Review.

2

Structural basis of assembly chaperone- mediated snRNP formation.

Grimm C, Chari A, Pelz JP, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U. Grimm C, et al. Among authors: chari a. Mol Cell. 2013 Feb 21;49(4):692-703. doi: 10.1016/j.molcel.2012.12.009. Epub 2013 Jan 17. Mol Cell. 2013. PMID: 23333303 Free article.

3

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.

Chari A, Haselbach D, Kirves JM, Ohmer J, Paknia E, Fischer N, Ganichkin O, Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H. Chari A, et al. Nat Methods. 2015 Sep;12(9):859-65. doi: 10.1038/nmeth.3493. Epub 2015 Aug 3. Nat Methods. 2015. PMID: 26237227 Free PMC article.

4

Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy.

Stark H, Chari A. Stark H, et al. Among authors: chari a. Microscopy (Oxf). 2016 Feb;65(1):23-34. doi: 10.1093/jmicro/dfv367. Epub 2015 Dec 15. Microscopy (Oxf). 2016. PMID: 26671943 Review.

5

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

Schrader J, Henneberg F, Mata RA, Tittmann K, Schneider TR, Stark H, Bourenkov G, Chari A. Schrader J, et al. Among authors: chari a. Science. 2016 Aug 5;353(6299):594-8. doi: 10.1126/science.aaf8993. Science. 2016. PMID: 27493187

6

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome.

Rauhut R, Fabrizio P, Dybkov O, Hartmuth K, Pena V, Chari A, Kumar V, Lee CT, Urlaub H, Kastner B, Stark H, Lührmann R. Rauhut R, et al. Among authors: chari a. Science. 2016 Sep 23;353(6306):1399-1405. doi: 10.1126/science.aag1906. Epub 2016 Aug 25. Science. 2016. PMID: 27562955

7

The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

Paknia E, Chari A, Stark H, Fischer U. Paknia E, et al. Among authors: chari a. Cell Rep. 2016 Sep 20;16(12):3103-3112. doi: 10.1016/j.celrep.2016.08.047. Cell Rep. 2016. PMID: 27653676 Free article.

8

Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.

Haselbach D, Schrader J, Lambrecht F, Henneberg F, Chari A, Stark H. Haselbach D, et al. Among authors: chari a. Nat Commun. 2017 May 25;8:15578. doi: 10.1038/ncomms15578. Nat Commun. 2017. PMID: 28541292 Free PMC article.

9

Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.

Prajapati S, Haselbach D, Wittig S, Patel MS, Chari A, Schmidt C, Stark H, Tittmann K. Prajapati S, et al. Among authors: chari a. Structure. 2019 Jul 2;27(7):1124-1136.e4. doi: 10.1016/j.str.2019.04.009. Epub 2019 May 23. Structure. 2019. PMID: 31130485 Free article.

10

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.

Singh K, Graf B, Linden A, Sautner V, Urlaub H, Tittmann K, Stark H, Chari A. Singh K, et al. Among authors: chari a. Cell. 2020 Mar 19;180(6):1130-1143.e20. doi: 10.1016/j.cell.2020.02.034. Epub 2020 Mar 10. Cell. 2020. PMID: 32160528 Free article.

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