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Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW. Bakowski MA, et al. Among authors: chappell l. Sci Transl Med. 2019 May 8;11(491):eaav3523. doi: 10.1126/scitranslmed.aav3523. Sci Transl Med. 2019. PMID: 31068442
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Hübner MP, Gunderson E, Vogel I, Bulman CA, Lim KC, Koschel M, Ehrens A, Frohberger SJ, Fendler M, Tricoche N, Voronin D, Steven A, Chi V, Bakowski MA, Woods AK, Petrassi HM, McNamara CW, Beerntsen B, Chappell L, Sullivan W, Taylor MJ, Turner JD, Hoerauf A, Lustigman S, Sakanari JA. Hübner MP, et al. Among authors: chappell l. Int J Parasitol Drugs Drug Resist. 2020 Apr;12:18-27. doi: 10.1016/j.ijpddr.2019.12.001. Epub 2019 Dec 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 31869759 Free PMC article.
A symbiont's guide to the germline.
Russell SL, Chappell L, Sullivan W. Russell SL, et al. Among authors: chappell l. Curr Top Dev Biol. 2019;135:315-351. doi: 10.1016/bs.ctdb.2019.04.007. Epub 2019 May 9. Curr Top Dev Biol. 2019. PMID: 31155362 Review.
The Eagle effect in the Wolbachia-worm symbiosis.
Bulman CA, Chappell L, Gunderson E, Vogel I, Beerntsen B, Slatko BE, Sullivan W, Sakanari JA. Bulman CA, et al. Among authors: chappell l. Parasit Vectors. 2021 Feb 24;14(1):118. doi: 10.1186/s13071-020-04545-w. Parasit Vectors. 2021. PMID: 33627171 Free PMC article.
The endosymbiont Wolbachia rebounds following antibiotic treatment.
Gunderson EL, Vogel I, Chappell L, Bulman CA, Lim KC, Luo M, Whitman JD, Franklin C, Choi YJ, Lefoulon E, Clark T, Beerntsen B, Slatko B, Mitreva M, Sullivan W, Sakanari JA. Gunderson EL, et al. Among authors: chappell l. PLoS Pathog. 2020 Jul 8;16(7):e1008623. doi: 10.1371/journal.ppat.1008623. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32639986 Free PMC article.
440 results