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Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.
Shen Y, Connolly E, Aiello M, Zhou C, Chappa P, Song H, Tippitak P, Clark T, Cardenas M, Prokhnevska N, Mariniello A, Pagadala MS, Dhere VR, Rafiq S, Kesarwala AH, Orthwein A, Thomas SN, Khan MK, Brandon Dixon J, Lesinski GB, Lowe MC, Kissick H, Yu DS, Paulos CM, Schmitt NC, Buchwald ZS. Shen Y, et al. Among authors: chappa p. Res Sq [Preprint]. 2024 Mar 6:rs.3.rs-3921977. doi: 10.21203/rs.3.rs-3921977/v1. Res Sq. 2024. PMID: 38496632 Free PMC article. Preprint.
Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS.
Jansen CS, Prabhu RS, Pagadala MS, Chappa P, Goyal S, Zhou C, Neill SG, Prokhnevska N, Cardenas M, Hoang KB, Zhong J, Torres M, Logan S, Olson JJ, Nduom EK, Del Balzo L, Patel K, Burri SH, Asher AL, Wilkinson S, Lake R, Higgins KA, Patel P, Dhere V, Sowalsky AG, Khan MK, Kissick H, Buchwald ZS. Jansen CS, et al. Among authors: chappa p. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2722744. doi: 10.21203/rs.3.rs-2722744/v1. Res Sq. 2023. PMID: 36993444 Free PMC article. Preprint.
Lectins identify glycan biomarkers on glioblastoma-derived cancer stem cells.
Tucker-Burden C, Chappa P, Krishnamoorthy M, Gerwe BA, Scharer CD, Heimburg-Molinaro J, Harris W, Usta SN, Eilertson CD, Hadjipanayis CG, Stice SL, Brat DJ, Nash RJ. Tucker-Burden C, et al. Among authors: chappa p. Stem Cells Dev. 2012 Sep 1;21(13):2374-86. doi: 10.1089/scd.2011.0369. Epub 2012 Apr 27. Stem Cells Dev. 2012. PMID: 22435486 Free PMC article.