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Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.
Aging Cell. 2022 Jan;21(1):e13488. doi: 10.1111/acel.13488. Epub 2021 Nov 27.
Aging Cell. 2022.
PMID: 34837316
Free PMC article.
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC.
Lucanic M, et al. Among authors: chao ea.
Nat Commun. 2017 Feb 21;8:14256. doi: 10.1038/ncomms14256.
Nat Commun. 2017.
PMID: 28220799
Free PMC article.
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