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Page 1
Showing results for channel kb
Search for Chantal KB instead (1 results)
New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.
Zaika O, Tomilin V, Mamenko M, Bhalla V, Pochynyuk O. Zaika O, et al. Am J Physiol Renal Physiol. 2016 May 15;310(10):F923-30. doi: 10.1152/ajprenal.00577.2015. Epub 2016 Jan 20. Am J Physiol Renal Physiol. 2016. PMID: 26792067 Free PMC article. Review.
Considerable experimental and clinical effort has been devoted to the identification and characterization of disease-causing mutations as well as control of the channel by its cofactor, barttin. However, we have only begun to unravel the role of ClC-Kb/2 in differen …
Considerable experimental and clinical effort has been devoted to the identification and characterization of disease-causing mutations as we …
Bartter syndrome.
Hebert SC. Hebert SC. Curr Opin Nephrol Hypertens. 2003 Sep;12(5):527-32. doi: 10.1097/00041552-200309000-00008. Curr Opin Nephrol Hypertens. 2003. PMID: 12920401 Review.
RECENT FINDINGS: Previously, three genes (SLC12A2, the sodium-potassium-chloride co-transporter; KCNJ1, the ROMK potassium ion channel; ClC-Kb, the basolateral chloride ion channel) had been identified as causing antenatal and 'classic' Bartter syndrome. ...B …
RECENT FINDINGS: Previously, three genes (SLC12A2, the sodium-potassium-chloride co-transporter; KCNJ1, the ROMK potassium ion channel …
CLC channel function and dysfunction in health and disease.
Stölting G, Fischer M, Fahlke C. Stölting G, et al. Front Physiol. 2014 Oct 7;5:378. doi: 10.3389/fphys.2014.00378. eCollection 2014. Front Physiol. 2014. PMID: 25339907 Free PMC article. Review.
CLC channels and transporters are expressed in most tissues and fulfill diverse functions. There are four human CLC channels, ClC-1, ClC-2, ClC-Ka, and ClC-Kb, and five CLC transporters, ClC-3 through -7. ...
CLC channels and transporters are expressed in most tissues and fulfill diverse functions. There are four human CLC channels, …
ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3.
Andrini O, Keck M, Briones R, Lourdel S, Vargas-Poussou R, Teulon J. Andrini O, et al. Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1324-34. doi: 10.1152/ajprenal.00004.2015. Epub 2015 Mar 25. Am J Physiol Renal Physiol. 2015. PMID: 25810436 Free article. Review.
The mutations in the CLCNKB gene encoding the ClC-Kb chloride channel are responsible for Bartter syndrome type 3, one of the four variants of Bartter syndrome in the genetically based nomenclature. ...However, only 20 CLCNKB mutations have been functionally analyze …
The mutations in the CLCNKB gene encoding the ClC-Kb chloride channel are responsible for Bartter syndrome type 3, one of the …
The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction.
Pezier A, Bobkov YV, Ache BW. Pezier A, et al. J Neurophysiol. 2009 Mar;101(3):1151-9. doi: 10.1152/jn.90903.2008. Epub 2008 Dec 31. J Neurophysiol. 2009. PMID: 19118110 Free PMC article.
Given evidence that the Na(+)/Ca(2+) exchange inhibitor, KB-R7943, blocks mammalian TRPC channels, we studied this probe as a potential blocker of the lobster SGC channel. ...KB-R7943 decreased the channel open probability without changing singl …
Given evidence that the Na(+)/Ca(2+) exchange inhibitor, KB-R7943, blocks mammalian TRPC channels, we studied this probe as a …
Carboxyl-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking.
Stölting G, Bungert-Plümke S, Franzen A, Fahlke C. Stölting G, et al. J Biol Chem. 2015 Dec 18;290(51):30406-16. doi: 10.1074/jbc.M115.675827. Epub 2015 Oct 9. J Biol Chem. 2015. PMID: 26453302 Free PMC article.
Mutations in CLCNKB, the gene encoding the renal chloride channel hClC-Kb, cause Bartter syndrome type III, a human genetic condition characterized by polyuria, hypokalemia, and alkalosis. ...W610X attenuates hClC-Kb surface membrane insertion. Moreover, W610 …
Mutations in CLCNKB, the gene encoding the renal chloride channel hClC-Kb, cause Bartter syndrome type III, a human genetic co …
Volume-sensitive Cl(-) channel as a regulator of acquired cisplatin resistance.
Shimizu T, Lee EL, Ise T, Okada Y. Shimizu T, et al. Anticancer Res. 2008 Jan-Feb;28(1A):75-83. Anticancer Res. 2008. PMID: 18383827 Free article. Review.
Recently, many studies have pointed to the involvement of plasma membrane ion channels in a cell's response to cisplatin. Our group has found that pretreatment with cisplatin enhanced the activity of volume-sensitive C-channels in human epidermoid cancer KB c …
Recently, many studies have pointed to the involvement of plasma membrane ion channels in a cell's response to cisplatin. Our group h …
In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening.
Louet M, Bitam S, Bakouh N, Bignon Y, Planelles G, Lagorce D, Miteva MA, Eladari D, Teulon J, Villoutreix BO. Louet M, et al. Sci Rep. 2017 Aug 3;7(1):7249. doi: 10.1038/s41598-017-07794-5. Sci Rep. 2017. PMID: 28775266 Free PMC article.
The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potential therape …
The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter s …
Analysis of CLCNKB mutations at dimer-interface, calcium-binding site, and pore reveals a variety of functional alterations in ClC-Kb channel leading to Bartter syndrome.
Bignon Y, Sakhi I, Bitam S, Bakouh N, Keck M, Frachon N, Paulais M, Planelles G, Teulon J, Andrini O. Bignon Y, et al. Hum Mutat. 2020 Apr;41(4):774-785. doi: 10.1002/humu.23962. Epub 2019 Dec 24. Hum Mutat. 2020. PMID: 31803959
Pathological missense mutations in CLCNKB gene give a wide spectrum of clinical phenotypes in Bartter syndrome type III patients. Molecular analysis of the mutated ClC-Kb channels can be helpful to classify the mutations according to their functional alteration. ... …
Pathological missense mutations in CLCNKB gene give a wide spectrum of clinical phenotypes in Bartter syndrome type III patients. Molecular …
Genetic causes of hypercalciuric nephrolithiasis.
Stechman MJ, Loh NY, Thakker RV. Stechman MJ, et al. Pediatr Nephrol. 2009 Dec;24(12):2321-32. doi: 10.1007/s00467-008-0807-0. Epub 2008 Apr 30. Pediatr Nephrol. 2009. PMID: 18446382 Free PMC article. Review.
Bartter syndrome, Dent's disease, autosomal dominant hypocalcemic hypercalciuria (ADHH), hypercalciuric nephrolithiasis with hypophosphatemia, and familial hypomagnesemia with hypercalciuria have helped to identify a number of transporters, channels and receptors that are …
Bartter syndrome, Dent's disease, autosomal dominant hypocalcemic hypercalciuria (ADHH), hypercalciuric nephrolithiasis with hypophosphatemi …
1,997 results