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Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Wang H, Yu N, Chen D, Lee KC, Lye PL, Chang JW, Deng W, Ng MC, Lu T, Khoo ML, Poulsen A, Sangthongpitag K, Wu X, Hu C, Goh KC, Wang X, Fang L, Goh KL, Khng HH, Goh SK, Yeo P, Liu X, Bonday Z, Wood JM, Dymock BW, Kantharaj E, Sun ET. Wang H, et al. Among authors: chang jw. J Med Chem. 2011 Jul 14;54(13):4694-720. doi: 10.1021/jm2003552. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21634430
Practical copper(I)-catalysed amidation of aldehydes.
Chang JW, Ton TM, Tania S, Taylor PC, Chan PW. Chang JW, et al. Chem Commun (Camb). 2010 Feb 14;46(6):922-4. doi: 10.1039/b918588g. Epub 2009 Dec 4. Chem Commun (Camb). 2010. PMID: 20107651
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies.
Skeate JG, Pomeroy EJ, Slipek NJ, Jones BJ, Wick BJ, Chang JW, Lahr WS, Stelljes EM, Patrinostro X, Barnes B, Zarecki T, Krueger JB, Bridge JE, Robbins GM, McCormick MD, Leerar JR, Wenzel KT, Hornberger KM, Walker K, Smedley D, Largaespada DA, Otto N, Webber BR, Moriarity BS. Skeate JG, et al. Among authors: chang jw. Mol Ther. 2024 Apr 16:S1525-0016(24)00241-7. doi: 10.1016/j.ymthe.2024.04.024. Online ahead of print. Mol Ther. 2024. PMID: 38627969 Free article.
1,130 results