Chang G - Search Results

1

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Among authors: chang g. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681

2

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD. Varma MV, et al. Among authors: chang g. J Med Chem. 2010 Feb 11;53(3):1098-108. doi: 10.1021/jm901371v. J Med Chem. 2010. PMID: 20070106

3

Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion.

Varma MV, Chang G, Lai Y, Feng B, El-Kattan AF, Litchfield J, Goosen TC. Varma MV, et al. Among authors: chang g. Drug Metab Dispos. 2012 Aug;40(8):1527-37. doi: 10.1124/dmd.112.044628. Epub 2012 May 11. Drug Metab Dispos. 2012. PMID: 22580868

4

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Among authors: chang g. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

5

Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery.

Chang G, Steyn SJ, Umland JP, Scott DO. Chang G, et al. ACS Med Chem Lett. 2010 Feb 3;1(2):50-3. doi: 10.1021/ml900012h. eCollection 2010 May 13. ACS Med Chem Lett. 2010. PMID: 24900175 Free PMC article.

6

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.

Riccardi K, Ryu S, Lin J, Yates P, Tess D, Li R, Singh D, Holder BR, Kapinos B, Chang G, Di L. Riccardi K, et al. Among authors: chang g. Drug Metab Dispos. 2018 Apr;46(4):415-421. doi: 10.1124/dmd.117.079152. Epub 2018 Feb 2. Drug Metab Dispos. 2018. PMID: 29437874

7

Evaluation of Fraction Unbound Across 7 Tissues of 5 Species.

Ryu S, Tess D, Chang G, Keefer C, Burchett W, Steeno GS, Novak JJ, Patel R, Atkinson K, Riccardi K, Di L. Ryu S, et al. Among authors: chang g. J Pharm Sci. 2020 Feb;109(2):1178-1190. doi: 10.1016/j.xphs.2019.10.060. Epub 2019 Nov 5. J Pharm Sci. 2020. PMID: 31704191

8

Structural attributes influencing unbound tissue distribution.

Orozco CC, Atkinson K, Ryu S, Chang G, Keefer C, Lin J, Riccardi K, Mongillo RK, Tess D, Filipski KJ, Kalgutkar AS, Litchfield J, Scott D, Di L. Orozco CC, et al. Among authors: chang g. Eur J Med Chem. 2020 Jan 1;185:111813. doi: 10.1016/j.ejmech.2019.111813. Epub 2019 Oct 28. Eur J Med Chem. 2020. PMID: 31732255

9

Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes.

Keefer C, Chang G, Carlo A, Novak JJ, Banker M, Carey J, Cianfrogna J, Eng H, Jagla C, Johnson N, Jones R, Jordan S, Lazzaro S, Liu J, Scott Obach R, Riccardi K, Tess D, Umland J, Racich J, Varma M, Visswanathan R, Di L. Keefer C, et al. Among authors: chang g. Eur J Pharm Sci. 2020 Dec 1;155:105541. doi: 10.1016/j.ejps.2020.105541. Epub 2020 Sep 12. Eur J Pharm Sci. 2020. PMID: 32927071

10

Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods.

Mathew S, Tess D, Burchett W, Chang G, Woody N, Keefer C, Orozco C, Lin J, Jordan S, Yamazaki S, Jones R, Di L. Mathew S, et al. Among authors: chang g. J Pharm Sci. 2021 Apr;110(4):1799-1823. doi: 10.1016/j.xphs.2020.12.005. Epub 2020 Dec 16. J Pharm Sci. 2021. PMID: 33338491

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