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Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro.
Herath HMPD, Preston S, Jabbar A, Garcia-Bustos J, Addison RS, Hayes S, Rali T, Wang T, Koehler AV, Chang BCH, Hofmann A, Davis RA, Gasser RB. Herath HMPD, et al. Among authors: chang bch. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:72-79. doi: 10.1016/j.ijpddr.2018.12.006. Epub 2019 Jan 4. Int J Parasitol Drugs Drug Resist. 2019. PMID: 30739078 Free PMC article.
Phylogenomic and biogeographic reconstruction of the Trichinella complex.
Korhonen PK, Pozio E, La Rosa G, Chang BC, Koehler AV, Hoberg EP, Boag PR, Tan P, Jex AR, Hofmann A, Sternberg PW, Young ND, Gasser RB. Korhonen PK, et al. Nat Commun. 2016 Feb 1;7:10513. doi: 10.1038/ncomms10513. Nat Commun. 2016. PMID: 26830005 Free PMC article.
Whipworm kinomes reflect a unique biology and adaptation to the host animal.
Stroehlein AJ, Young ND, Korhonen PK, Chang BCH, Nejsum P, Pozio E, La Rosa G, Sternberg PW, Gasser RB. Stroehlein AJ, et al. Among authors: chang bch. Int J Parasitol. 2017 Nov;47(13):857-866. doi: 10.1016/j.ijpara.2017.04.005. Epub 2017 Jun 10. Int J Parasitol. 2017. PMID: 28606697
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain.
Preston S, Korhonen PK, Mouchiroud L, Cornaglia M, McGee SL, Young ND, Davis RA, Crawford S, Nowell C, Ansell BRE, Fisher GM, Andrews KT, Chang BCH, Gijs MAM, Sternberg PW, Auwerx J, Baell J, Hofmann A, Jabbar A, Gasser RB. Preston S, et al. Among authors: chang bch. FASEB J. 2017 Oct;31(10):4515-4532. doi: 10.1096/fj.201700288R. Epub 2017 Jul 7. FASEB J. 2017. PMID: 28687609
Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro.
Dilrukshi Herath HMP, Song H, Preston S, Jabbar A, Wang T, McGee SL, Hofmann A, Garcia-Bustos J, Chang BCH, Koehler AV, Liu Y, Ma Q, Zhang P, Zhao Q, Wang Q, Gasser RB. Dilrukshi Herath HMP, et al. Among authors: chang bch. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):379-385. doi: 10.1016/j.ijpddr.2018.06.002. Epub 2018 Jun 4. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30081296 Free PMC article.
Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.
Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Jabbar A, Wells TNC, Palmer MJ, Gasser RB, Baell JB. Le TG, et al. Among authors: chang bch. J Med Chem. 2018 Dec 13;61(23):10875-10894. doi: 10.1021/acs.jmedchem.8b01544. Epub 2018 Nov 29. J Med Chem. 2018. PMID: 30403349
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