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Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning.
Manak MS, Varsanik JS, Hogan BJ, Whitfield MJ, Su WR, Joshi N, Steinke N, Min A, Berger D, Saphirstein RJ, Dixit G, Meyyappan T, Chu HM, Knopf KB, Albala DM, Sant GR, Chander AC. Manak MS, et al. Among authors: chander ac. Nat Biomed Eng. 2018 Oct;2(10):761-772. doi: 10.1038/s41551-018-0285-z. Epub 2018 Sep 17. Nat Biomed Eng. 2018. PMID: 30854249 Free PMC article.
Clinical Proof-of-concept of a Novel Platform Utilizing Biopsy-derived Live Single Cells, Phenotypic Biomarkers, and Machine Learning Toward a Precision Risk Stratification Test for Prostate Cancer Grade Groups 1 and 2 (Gleason 3 + 3 and 3 + 4).
Albala D, Manak MS, Varsanik JS, Rashid HH, Mouraviev V, Zappala SM, Ette E, Kella N, Rieger-Christ KM, Sant GR, Chander AC. Albala D, et al. Among authors: chander ac. Urology. 2019 Feb;124:198-206. doi: 10.1016/j.urology.2018.09.032. Epub 2018 Oct 10. Urology. 2019. PMID: 30312670
α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions.
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP. Meacci G, et al. Among authors: chander ac. Mol Biol Cell. 2016 Nov 7;27(22):3471-3479. doi: 10.1091/mbc.E16-02-0107. Epub 2016 Apr 27. Mol Biol Cell. 2016. PMID: 27122603 Free PMC article.