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NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.
Levine DC, Kuo HY, Hong HK, Cedernaes J, Hepler C, Wright AG, Sommars MA, Kobayashi Y, Marcheva B, Gao P, Ilkayeva OR, Omura C, Ramsey KM, Newgard CB, Barish GD, Peek CB, Chandel NS, Mrksich M, Bass J. Levine DC, et al. Among authors: chandel ns. Nat Metab. 2021 Dec;3(12):1621-1632. doi: 10.1038/s42255-021-00498-1. Epub 2021 Dec 13. Nat Metab. 2021. PMID: 34903884 Free PMC article.
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J. Peek CB, et al. Among authors: chandel ns. Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19. Science. 2013. PMID: 24051248 Free PMC article.
Hexokinase 2 is dispensable for T cell-dependent immunity.
Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS. Mehta MM, et al. Among authors: chandel ns. Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5. eCollection 2018. Cancer Metab. 2018. PMID: 30140438 Free PMC article.
IDH3α regulates one-carbon metabolism in glioblastoma.
May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH. May JL, et al. Among authors: chandel ns. Sci Adv. 2019 Jan 2;5(1):eaat0456. doi: 10.1126/sciadv.aat0456. eCollection 2019 Jan. Sci Adv. 2019. PMID: 30613765 Free PMC article.
Mitochondrial complex III is essential for suppressive function of regulatory T cells.
Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS. Weinberg SE, et al. Among authors: chandel ns. Nature. 2019 Jan;565(7740):495-499. doi: 10.1038/s41586-018-0846-z. Epub 2019 Jan 9. Nature. 2019. PMID: 30626970 Free PMC article.
Mitochondrial ubiquinol oxidation is necessary for tumour growth.
Martínez-Reyes I, Cardona LR, Kong H, Vasan K, McElroy GS, Werner M, Kihshen H, Reczek CR, Weinberg SE, Gao P, Steinert EM, Piseaux R, Budinger GRS, Chandel NS. Martínez-Reyes I, et al. Among authors: chandel ns. Nature. 2020 Sep;585(7824):288-292. doi: 10.1038/s41586-020-2475-6. Epub 2020 Jul 8. Nature. 2020. PMID: 32641834 Free PMC article.
We need to talk about the Warburg effect.
DeBerardinis RJ, Chandel NS. DeBerardinis RJ, et al. Among authors: chandel ns. Nat Metab. 2020 Feb;2(2):127-129. doi: 10.1038/s42255-020-0172-2. Nat Metab. 2020. PMID: 32694689 No abstract available.
316 results