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Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.
Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ Jr, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Chan YK, et al. Among authors: chan y. Sci Transl Med. 2021 Feb 10;13(580):eabd3438. doi: 10.1126/scitranslmed.abd3438. Sci Transl Med. 2021. PMID: 33568518 Free PMC article.
Adeno-associated Virus (AAV) versus Immune Response.
Rabinowitz J, Chan YK, Samulski RJ. Rabinowitz J, et al. Among authors: chan yk. Viruses. 2019 Jan 25;11(2):102. doi: 10.3390/v11020102. Viruses. 2019. PMID: 30691064 Free PMC article. Review.
Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Xiao Y, Muhuri M, Li S, Qin W, Xu G, Luo L, Li J, Letizia AJ, Wang SK, Chan YK, Wang C, Fuchs SP, Wang D, Su Q, Nahid MA, Church GM, Farzan M, Yang L, Wei Y, Desrosiers RC, Mueller C, Tai PW, Gao G. Xiao Y, et al. Among authors: chan yk. JCI Insight. 2019 May 21;5(13):e99052. doi: 10.1172/jci.insight.99052. JCI Insight. 2019. PMID: 31112525 Free PMC article.
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.
Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Lim ET, et al. Among authors: chan yk, chan y. Nat Commun. 2022 Jun 10;13(1):3243. doi: 10.1038/s41467-022-30968-3. Nat Commun. 2022. PMID: 35688811 Free PMC article.
Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration.
Liu J, Copland DA, Clare AJ, Gorski M, Richards BT, Scott L, Theodoropoulou S, Greferath U, Cox K, Bell OH, Ou K, Powell JLB, Wu J, Robles LM, Li Y, Nicholson LB, Coffey PJ, Fletcher EL, Guymer R, Radeke MJ, Heid IM, Hageman GS, Chan YK, Dick AD. Liu J, et al. Among authors: chan yk. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559733. doi: 10.1101/2023.09.27.559733. bioRxiv. 2023. PMID: 37808640 Free PMC article. Preprint.
Viral evasion of intracellular DNA and RNA sensing.
Chan YK, Gack MU. Chan YK, et al. Nat Rev Microbiol. 2016 Jun;14(6):360-73. doi: 10.1038/nrmicro.2016.45. Epub 2016 May 13. Nat Rev Microbiol. 2016. PMID: 27174148 Free PMC article. Review.
365 results