Chan S - Search Results

1

GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo.

Jiang K, Tang X, Guo J, He R, Chan S, Song X, Tu Z, Wang Y, Ren X, Ding K, Zhang Z. Jiang K, et al. Among authors: chan s. Cancer Med. 2021 Jul;10(14):4874-4884. doi: 10.1002/cam4.4041. Epub 2021 Jun 10. Cancer Med. 2021. PMID: 34114373 Free PMC article.

2

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

Chan S, Han K, Qu R, Tong L, Li Y, Zhang Z, Cheng H, Lu X, Patterson A, Smaill J, Ren X, Ding J, Xie H, Ding K. Chan S, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4277-81. doi: 10.1016/j.bmcl.2015.07.089. Epub 2015 Jul 30. Bioorg Med Chem Lett. 2015. PMID: 26259806

3

Discovery of JND3229 as a New EGFR^C797S Mutant Inhibitor with In Vivo Monodrug Efficacy.

Lu X, Zhang T, Zhu SJ, Xun Q, Tong L, Hu X, Li Y, Chan S, Su Y, Sun Y, Chen Y, Ding J, Yun CH, Xie H, Ding K. Lu X, et al. Among authors: chan s. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127. doi: 10.1021/acsmedchemlett.8b00373. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429956 Free PMC article.

4

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Tan L, Zhang Z, Gao D, Chan S, Luo J, Tu ZC, Zhang ZM, Ding K, Ren X, Lu X. Tan L, et al. Among authors: chan s. Eur J Med Chem. 2019 Mar 15;166:318-327. doi: 10.1016/j.ejmech.2019.01.065. Epub 2019 Jan 30. Eur J Med Chem. 2019. PMID: 30731400

5

GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In Vivo.

Wang Y, Zhang L, Tang X, Luo J, Tu Z, Jiang K, Ren X, Xu F, Chan S, Li Y, Zhang Z, Ding K. Wang Y, et al. Among authors: chan s. Transl Oncol. 2020 Apr;13(4):100766. doi: 10.1016/j.tranon.2020.100766. Epub 2020 Apr 1. Transl Oncol. 2020. PMID: 32247263 Free PMC article.

6

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: chan s. Mol Cancer. 2020 May 13;19(1):90. doi: 10.1186/s12943-020-01202-9. Mol Cancer. 2020. PMID: 32404161 Free PMC article.

7

Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors.

Duan Y, Wang J, Zhu S, Tu ZC, Zhang Z, Chan S, Ding K. Duan Y, et al. Among authors: chan s. Eur J Med Chem. 2020 Oct 1;203:112552. doi: 10.1016/j.ejmech.2020.112552. Epub 2020 Jul 13. Eur J Med Chem. 2020. PMID: 32702585

8

Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Among authors: chan s. Mol Cancer. 2021 Aug 17;20(1):102. doi: 10.1186/s12943-021-01391-x. Mol Cancer. 2021. PMID: 34404402 Free PMC article. No abstract available.

9

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Li S, Si H, Song X, Lei C, He X, Wang J, Liu Y, Zhou Y, Song JG, Peng L, Tang X, Chan S, Ren X, Tu Z, Li Z, Wang Z, Zhang Z, Ding K. Li S, et al. Among authors: chan s. J Med Chem. 2022 Aug 11;65(15):10674-10690. doi: 10.1021/acs.jmedchem.2c00922. Epub 2022 Jul 20. J Med Chem. 2022. PMID: 35860875

10

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo.

Wang J, Zhou Y, Tang X, Yu X, Wang Y, Chan S, Song X, Tu Z, Zhang Z, Lu X, Zhang Z, Ding K. Wang J, et al. Among authors: chan s. Molecules. 2022 Oct 1;27(19):6500. doi: 10.3390/molecules27196500. Molecules. 2022. PMID: 36235036 Free PMC article.

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