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Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity.
Samuelsson AS, Mullier A, Maicas N, Oosterhuis NR, Eun Bae S, Novoselova TV, Chan LF, Pombo JM, Taylor PD, Joles JA, Coen CW, Balthasar N, Poston L. Samuelsson AS, et al. Among authors: chan lf. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12298-12303. doi: 10.1073/pnas.1607464113. Epub 2016 Oct 6. Proc Natl Acad Sci U S A. 2016. PMID: 27791019 Free PMC article.
MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.
Chan LF, Webb TR, Chung TT, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA, Clark AJ. Chan LF, et al. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6146-51. doi: 10.1073/pnas.0809918106. Epub 2009 Mar 27. Proc Natl Acad Sci U S A. 2009. PMID: 19329486 Free PMC article.
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. Asai M, et al. Among authors: chan lf. Science. 2013 Jul 19;341(6143):275-8. doi: 10.1126/science.1233000. Science. 2013. PMID: 23869016 Free PMC article.
Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project; O'Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Novoselova TV, et al. Among authors: chan lf. J Endocrinol. 2016 Jul;230(1):13-26. doi: 10.1530/JOE-16-0057. Epub 2016 Apr 22. J Endocrinol. 2016. PMID: 27106110 Free PMC article.
Pathophysiology of melanocortin receptors and their accessory proteins.
Novoselova TV, Chan LF, Clark AJL. Novoselova TV, et al. Among authors: chan lf. Best Pract Res Clin Endocrinol Metab. 2018 Apr;32(2):93-106. doi: 10.1016/j.beem.2018.02.002. Epub 2018 Feb 9. Best Pract Res Clin Endocrinol Metab. 2018. PMID: 29678289 Free article. Review.
126 results