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NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling.
Zhang T, He X, Caldwell L, Goru SK, Ulloa Severino L, Tolosa MF, Misra PS, McEvoy CM, Christova T, Liu Y, Atin C, Zhang J, Hu C, Vukosa N, Chen X, Krizova A, Kirpalani A, Gregorieff A, Ni R, Chan K, Gill MK, Attisano L, Wrana JL, Yuen DA. Zhang T, et al. Among authors: chan k. Sci Transl Med. 2022 Mar 23;14(637):eaaz4028. doi: 10.1126/scitranslmed.aaz4028. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320001
Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Gilbert RE, Caldwell L, Misra PS, Chan K, Burns KD, Wrana JL, Yuen DA. Gilbert RE, et al. Among authors: chan k. Can J Diabetes. 2021 Mar;45(2):162-166.e1. doi: 10.1016/j.jcjd.2020.07.003. Epub 2020 Jul 18. Can J Diabetes. 2021. PMID: 32917504 Free PMC article.
A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2.
Aynaud MM, Hernandez JJ, Barutcu S, Braunschweig U, Chan K, Pearson JD, Trcka D, Prosser SL, Kim J, Barrios-Rodiles M, Jen M, Song S, Shen J, Bruce C, Hazlett B, Poutanen S, Attisano L, Bremner R, Blencowe BJ, Mazzulli T, Han H, Pelletier L, Wrana JL. Aynaud MM, et al. Among authors: chan k. Nat Commun. 2021 Mar 3;12(1):1405. doi: 10.1038/s41467-021-21653-y. Nat Commun. 2021. PMID: 33658502 Free PMC article.
Comparison of SARS-CoV-2 indirect and direct RT-qPCR detection methods.
Pearson JD, Trcka D, Lu S, Hyduk SJ, Jen M, Aynaud MM, Hernández JJ, Peidis P, Barrios-Rodiles M, Chan K, Woodgett J, Mazzulli T, Attisano L, Pelletier L, Cybulsky MI, Wrana JL, Bremner R. Pearson JD, et al. Among authors: chan k. Virol J. 2021 May 17;18(1):99. doi: 10.1186/s12985-021-01574-4. Virol J. 2021. PMID: 34001180 Free PMC article.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F. Posternak G, et al. Among authors: chan k. Nat Chem Biol. 2020 Nov;16(11):1170-1178. doi: 10.1038/s41589-020-0609-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778845 Free PMC article.
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