Chan EC - Search Results

1

Physiologically-based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID-19.

Ng TM, Wang Z, Chan ECY. Ng TM, et al. Among authors: chan ecy. Br J Clin Pharmacol. 2024 Apr 14. doi: 10.1111/bcp.16074. Online ahead of print. Br J Clin Pharmacol. 2024. PMID: 38616514

2

CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control.

Leow JWH, Chan ECY. Leow JWH, et al. Among authors: chan ecy. Pharmacol Ther. 2024 Mar 22;258:108637. doi: 10.1016/j.pharmthera.2024.108637. Online ahead of print. Pharmacol Ther. 2024. PMID: 38521247 Review.

3

Novel Bioresorbable Drug-Eluting Mesh Scaffold for Therapy of Muscle Injury.

Chou YC, Hsu YH, Lee D, Yang JW, Yu YH, Chan EC, Liu SJ. Chou YC, et al. Among authors: chan ec. ACS Biomater Sci Eng. 2024 Apr 8;10(4):2595-2606. doi: 10.1021/acsbiomaterials.3c01669. Epub 2024 Mar 13. ACS Biomater Sci Eng. 2024. PMID: 38480510

4

Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations.

Wei W, Tang LWT, Verma RK, Fan H, Chan ECY. Wei W, et al. Among authors: chan ecy. J Chem Inf Model. 2024 Mar 25;64(6):2058-2067. doi: 10.1021/acs.jcim.3c01837. Epub 2024 Mar 8. J Chem Inf Model. 2024. PMID: 38457234

5

RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.

Joshi IV, Chan EC, Lack JB, Liu C, Druey KM. Joshi IV, et al. Among authors: chan ec. J Biol Chem. 2024 Apr;300(4):107127. doi: 10.1016/j.jbc.2024.107127. Epub 2024 Mar 2. J Biol Chem. 2024. PMID: 38432633 Free PMC article.

6

Ciprofol is primarily glucuronidated by UGT1A9 and predicted not to cause drug-drug interactions with typical substrates of CYP1A2, CYP2B6, and CYP2C19.

Hou L, Zhao Y, Zhao S, Zhang X, Yao X, Yang J, Wang Z, Chan ECY, Liu S. Hou L, et al. Among authors: chan ecy. Chem Biol Interact. 2024 Jan 5;387:110811. doi: 10.1016/j.cbi.2023.110811. Epub 2023 Nov 20. Chem Biol Interact. 2024. PMID: 37993078

7

A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells.

Wojciech L, Png CW, Koh EY, Kioh DYQ, Deng L, Wang Z, Wu LZ, Hamidinia M, Tung DW, Zhang W, Pettersson S, Chan ECY, Zhang Y, Tan KS, Gascoigne NR. Wojciech L, et al. Among authors: chan ecy. EMBO J. 2023 Nov 2;42(21):e112963. doi: 10.15252/embj.2022112963. Epub 2023 Sep 25. EMBO J. 2023. PMID: 37743772 Free PMC article.

8

Advances in urinary biomarker research of synthetic cannabinoids.

Wang Z, Leow EYQ, Moy HY, Chan ECY. Wang Z, et al. Among authors: chan ecy. Adv Clin Chem. 2023;115:1-32. doi: 10.1016/bs.acc.2023.03.004. Epub 2023 Mar 28. Adv Clin Chem. 2023. PMID: 37673518

9

Unraveling Complexities in the Absorption and Disposition Kinetics of Abiraterone via Iterative PBPK Model Development and Refinement.

Cheong EJY, Chin SY, Ng ZW, Yap TJ, Cheong EZB, Wang Z, Chan ECY. Cheong EJY, et al. Among authors: chan ecy. Clin Pharmacokinet. 2023 Sep;62(9):1243-1261. doi: 10.1007/s40262-023-01266-y. Epub 2023 Jul 5. Clin Pharmacokinet. 2023. PMID: 37405634

10

Sensitive LC-MS/MS method for the temporal profiling of bile acids, fatty acids and branched-chain alpha-keto acids in maternal plasma during pregnancy and cord blood plasma at delivery.

Ng DZW, Lee SXY, Ooi DSQ, Ta LDH, Yap GC, Tay CJX, Huang CH, Tham EH, Loo EXL, Shek LPC, Goh A, Bever HPSV, Teoh OH, Lee YS, Yap F, Tan KH, Chong YS, Chan SY, Eriksson JG, Godfrey KM, Lee BW, Chan ECY. Ng DZW, et al. Among authors: chan ecy. Clin Chim Acta. 2023 Jul 1;547:117449. doi: 10.1016/j.cca.2023.117449. Epub 2023 Jun 17. Clin Chim Acta. 2023. PMID: 37331549

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