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IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development.
Blasiak A, Lim JJ, Seah SGK, Kee T, Remus A, Chye H, Wong PS, Hooi L, Truong ATL, Le N, Chan CEZ, Desai R, Ding X, Hanson BJ, Chow EK, Ho D. Blasiak A, et al. Among authors: chan cez. Bioeng Transl Med. 2020 Dec 1;6(1):e10196. doi: 10.1002/btm2.10196. eCollection 2021 Jan. Bioeng Transl Med. 2020. PMID: 33532594 Free PMC article.
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Chan CEZ, Seah SGK, Chye H, Massey S, Torres M, Lim APC, Wong SKK, Neo JJY, Wong PS, Lim JH, Loh GSL, Wang D, Boyd-Kirkup JD, Guan S, Thakkar D, Teo GH, Purushotorman K, Hutchinson PE, Young BE, Low JG, MacAry PA, Hentze H, Prativadibhayankara VS, Ethirajulu K, Comer JE, Tseng CK, Barrett ADT, Ingram PJ, Brasel T, Hanson BJ. Chan CEZ, et al. PLoS One. 2021 Jun 23;16(6):e0253487. doi: 10.1371/journal.pone.0253487. eCollection 2021. PLoS One. 2021. PMID: 34161386 Free PMC article.
IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV-2 Intervention.
Blasiak A, Truong ATL, Wang P, Hooi L, Chye H, Tan SB, You K, Remus A, Allen DM, Chai LYA, Chan CEZ, Lye DCB, Tan GG, Seah SGK, Chow EK, Ho D. Blasiak A, et al. Among authors: chan cez. ACS Nano. 2022 Sep 27;16(9):15141-15154. doi: 10.1021/acsnano.2c06366. Epub 2022 Aug 17. ACS Nano. 2022. PMID: 35977379
First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.
Prativadibhayankaram VS, Lee LS, Lye D, Xiaoying X, Nellore R, Pendharkar V, Hentze H, Guan S, Ayers BJ, Seah SGK, Chye H, Talib NSN, Kaliaperumal N, Ong WY, Wong ZX, Au VB, Alok A, Connolly JE, Boyd-Kirkup JD, Ingram PJ, Hanson BJ, Ethirajulu K, O'Connell D, Chan CEZ. Prativadibhayankaram VS, et al. Among authors: chan cez. Infect Dis Ther. 2022 Oct;11(5):1999-2015. doi: 10.1007/s40121-022-00681-1. Epub 2022 Sep 4. Infect Dis Ther. 2022. PMID: 36058990 Free PMC article.
Bidirectional Evolution of SARS-CoV-2 Virus in Immunocompromised Hosts.
Chew CWY, Young BE, Tambyah PA, Vasoo S, Chan CEZ. Chew CWY, et al. Among authors: chan cez. Influenza Other Respir Viruses. 2024 Mar;18(3):e13266. doi: 10.1111/irv.13266. Influenza Other Respir Viruses. 2024. PMID: 38462553 Free PMC article. No abstract available.
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