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Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters.
Yuan S, Yin X, Meng X, Chan J, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan C, Poon V, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Sze KH, Zhang J, Chu H, Kok KH, To K, Jin DY, Sun R, Chanda S, Yuen KY. Yuan S, et al. Among authors: chan c, chan cc, chan j. Res Sq [Preprint]. 2020 Oct 7:rs.3.rs-86169. doi: 10.21203/rs.3.rs-86169/v1. Res Sq. 2020. PMID: 33052331 Free PMC article. Updated. Preprint.
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies.
Zhou D, Chan JF, Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Zhou D, et al. Among authors: chan jf, chan cc, chan cy. Cell Host Microbe. 2021 Apr 14;29(4):551-563.e5. doi: 10.1016/j.chom.2021.02.019. Epub 2021 Feb 25. Cell Host Microbe. 2021. PMID: 33657424 Free PMC article.
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Yuan S, et al. Among authors: chan jf, chan cc. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. Nature. 2021. PMID: 33727703
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters.
Zhang BZ, Wang X, Yuan S, Li W, Dou Y, Poon VK, Chan CC, Cai JP, Chik KK, Tang K, Chan CC, Hu YF, Hu JC, Badea SR, Gong HR, Lin X, Chu H, Li X, To KK, Liu L, Chen Z, Hung IF, Yuen KY, Chan JF, Huang JD. Zhang BZ, et al. Among authors: chan jf, chan cc. Emerg Microbes Infect. 2021 Dec;10(1):874-884. doi: 10.1080/22221751.2021.1921621. Emerg Microbes Infect. 2021. PMID: 33890550 Free PMC article.
In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor.
Wen L, Tang K, Chik KK, Chan CC, Tsang JO, Liang R, Cao J, Huang Y, Luo C, Cai JP, Ye ZW, Yin F, Chu H, Jin DY, Yuen KY, Yuan S, Chan JF. Wen L, et al. Among authors: chan jf, chan cc. Int J Biol Sci. 2021 Apr 10;17(6):1555-1564. doi: 10.7150/ijbs.59191. eCollection 2021. Int J Biol Sci. 2021. PMID: 33907519 Free PMC article.
Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.
Chan JFW, Poon VKM, Chan CCS, Chik KKH, Tsang JOL, Zou Z, Chan CCY, Lee ACY, Li C, Liang R, Cao J, Tang K, Yuen TTT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Chan JFW, et al. Clin Infect Dis. 2022 Aug 24;75(1):e1101-e1111. doi: 10.1093/cid/ciab817. Clin Infect Dis. 2022. PMID: 34536277
1,969 results