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14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2.
Woo MS, Nilsson J, Therriault J, Rahmouni N, Brinkmalm A, Benedet AL, Ashton NJ, Macedo AC, Servaes S, Wang YT, Tissot C, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Karikari TK, Stevenson J, Mayer C, Ferrari-Souza JP, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P. Woo MS, et al. Among authors: chamoun m. J Neuroinflammation. 2023 Nov 24;20(1):278. doi: 10.1186/s12974-023-02962-z. J Neuroinflammation. 2023. PMID: 38001539 Free PMC article.
APOEε4 potentiates the relationship between amyloid-β and tau pathologies.
Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Savard M, Chamoun M, Thomas E, Kang MS, Lussier F, Tissot C, Soucy JP, Massarweh G, Rej S, Saha-Chaudhuri P, Poirier J, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Therriault J, et al. Among authors: chamoun m. Mol Psychiatry. 2021 Oct;26(10):5977-5988. doi: 10.1038/s41380-020-0688-6. Epub 2020 Mar 11. Mol Psychiatry. 2021. PMID: 32161362 Free PMC article.
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K. Karikari TK, et al. Among authors: chamoun m. Lancet Neurol. 2020 May;19(5):422-433. doi: 10.1016/S1474-4422(20)30071-5. Lancet Neurol. 2020. PMID: 32333900
Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease.
Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, Soucy JP, Cuello AC, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Kang MS, et al. Among authors: chamoun m. Mol Psychiatry. 2021 Oct;26(10):5989-6001. doi: 10.1038/s41380-020-0818-1. Epub 2020 Jun 26. Mol Psychiatry. 2021. PMID: 32591633 Free PMC article.
Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease.
Therriault J, Pascoal TA, Savard M, Benedet AL, Chamoun M, Tissot C, Lussier F, Kang MS, Thomas E, Terada T, Rej S, Massarweh G, Nasreddine Z, Vitali P, Soucy JP, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Therriault J, et al. Among authors: chamoun m. Neurology. 2021 Jan 5;96(1):e81-e92. doi: 10.1212/WNL.0000000000011081. Epub 2020 Oct 22. Neurology. 2021. PMID: 33093220 Free PMC article.
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease.
Benedet AL, Leuzy A, Pascoal TA, Ashton NJ, Mathotaarachchi S, Savard M, Therriault J, Kang MS, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Rosa-Neto P, Blennow K; Alzheimer’s Disease Neuroimaging Initiative. Benedet AL, et al. Among authors: chamoun m. Brain. 2020 Dec 1;143(12):3793-3804. doi: 10.1093/brain/awaa342. Brain. 2020. PMID: 33210117 Free PMC article.
Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment.
Therriault J, Pascoal TA, Benedet AL, Tissot C, Savard M, Chamoun M, Lussier F, Kang MS, Berzgin G, Wang T, Fernandes-Arias J, Massarweh G, Soucy JP, Vitali P, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Therriault J, et al. Among authors: chamoun m. Neurology. 2021 Feb 16;96(7):e975-e985. doi: 10.1212/WNL.0000000000011416. Epub 2020 Dec 21. Neurology. 2021. PMID: 33443136 Free PMC article.
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: chamoun m. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. Nat Med. 2021. PMID: 34446931
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.
Pascoal TA, Benedet AL, Tudorascu DL, Therriault J, Mathotaarachchi S, Savard M, Lussier FZ, Tissot C, Chamoun M, Kang MS, Stevenson J, Massarweh G, Guiot MC, Soucy JP, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: chamoun m. Brain. 2021 Dec 16;144(11):3517-3528. doi: 10.1093/brain/awab248. Brain. 2021. PMID: 34515754 Free PMC article.
Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET.
Tissot C, Therriault J, Kunach P, L Benedet A, Pascoal TA, Ashton NJ, Karikari TK, Servaes S, Lussier FZ, Chamoun M, Tudorascu DL, Stevenson J, Rahmouni N, Poltronetti NM, Pallen V, Bezgin G, Kang MS, Mathotaarachchi SS, Wang YT, Fernandez Arias J, Ferreira PCL, Ferrari-Souza JP, Vanmechelen E, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Tissot C, et al. Among authors: chamoun m. EBioMedicine. 2022 Feb;76:103837. doi: 10.1016/j.ebiom.2022.103837. Epub 2022 Feb 6. EBioMedicine. 2022. PMID: 35134647 Free PMC article.
71 results