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DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs.
Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V. Robertson GL, et al. Among authors: chakrabarty rp. J Cell Sci. 2023 Feb 1;136(3):jcs260370. doi: 10.1242/jcs.260370. Epub 2023 Feb 10. J Cell Sci. 2023. PMID: 36763487 Free PMC article.
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG. Riechers SP, et al. Among authors: chakrabarty rp. Mol Metab. 2022 Jun;60:101468. doi: 10.1016/j.molmet.2022.101468. Epub 2022 Mar 3. Mol Metab. 2022. PMID: 35248787 Free PMC article.
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.
McElroy GS, Chakrabarty RP, D'Alessandro KB, Hu YS, Vasan K, Tan J, Stoolman JS, Weinberg SE, Steinert EM, Reyfman PA, Singer BD, Ladiges WC, Gao L, Lopéz-Barneo J, Ridge K, Budinger GRS, Chandel NS. McElroy GS, et al. Among authors: chakrabarty rp. Sci Rep. 2022 Mar 25;12(1):5196. doi: 10.1038/s41598-022-09074-3. Sci Rep. 2022. PMID: 35338200 Free PMC article.
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis.
Romero-Morales AI, Robertson GL, Rastogi A, Rasmussen ML, Temuri H, McElroy GS, Chakrabarty RP, Hsu L, Almonacid PM, Millis BA, Chandel NS, Cartailler JP, Gama V. Romero-Morales AI, et al. Among authors: chakrabarty rp. Development. 2022 Oct 15;149(20):dev199914. doi: 10.1242/dev.199914. Epub 2022 Jul 6. Development. 2022. PMID: 35792828 Free PMC article.
Beyond ATP, new roles of mitochondria.
Chakrabarty RP, Chandel NS. Chakrabarty RP, et al. Biochem (Lond). 2022 Aug;44(4):2-8. doi: 10.1042/bio_2022_119. Epub 2022 Aug 23. Biochem (Lond). 2022. PMID: 36248614 Free PMC article.
Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency.
Granat L, Knorr DY, Ranson DC, Hamer EL, Chakrabarty RP, Mattedi F, Fort-Aznar L, Hirth F, Sweeney ST, Vagnoni A, Chandel NS, Bateman JM. Granat L, et al. Among authors: chakrabarty rp. PLoS Genet. 2023 Jul 3;19(7):e1010793. doi: 10.1371/journal.pgen.1010793. eCollection 2023 Jul. PLoS Genet. 2023. PMID: 37399212 Free PMC article.
A Drosophila model of mitochondrial disease phenotypic heterogeneity.
Granat L, Knorr DY, Ranson DC, Chakrabarty RP, Chandel NS, Bateman JM. Granat L, et al. Among authors: chakrabarty rp. Biol Open. 2024 Feb 15;13(2):bio060278. doi: 10.1242/bio.060278. Epub 2024 Feb 28. Biol Open. 2024. PMID: 38304969 Free PMC article.
Author Correction: Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice.
McElroy GS, Chakrabarty RP, D'Alessandro KB, Hu YS, Vasan K, Tan J, Stoolman JS, Weinberg SE, Steinert EM, Reyfman PA, Singer BD, Ladiges WC, Gao L, Lopéz-Barneo J, Ridge K, Budinger GRS, Chandel NS. McElroy GS, et al. Among authors: chakrabarty rp. Sci Rep. 2022 May 17;12(1):8191. doi: 10.1038/s41598-022-12069-9. Sci Rep. 2022. PMID: 35581238 Free PMC article. No abstract available.
24 results