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Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.
Milighetti M, Peng Y, Tan C, Mark M, Nageswaran G, Byrne S, Ronel T, Peacock T, Mayer A, Chandran A, Rosenheim J, Whelan M, Yao X, Liu G, Felce SL, Dong T, Mentzer AJ, Knight JC, Balloux F, Greenstein E, Reich-Zeliger S, Pade C, Gibbons JM, Semper A, Brooks T, Otter A, Altmann DM, Boyton RJ, Maini MK, McKnight A, Manisty C, Treibel TA, Moon JC; COVIDsortium Investigators; Noursadeghi M, Chain B. Milighetti M, et al. Among authors: chain b. iScience. 2023 Jun 16;26(6):106937. doi: 10.1016/j.isci.2023.106937. Epub 2023 May 22. iScience. 2023. PMID: 37275518 Free PMC article.
Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence.
Thomas N, Best K, Cinelli M, Reich-Zeliger S, Gal H, Shifrut E, Madi A, Friedman N, Shawe-Taylor J, Chain B. Thomas N, et al. Among authors: chain b. Bioinformatics. 2014 Nov 15;30(22):3181-8. doi: 10.1093/bioinformatics/btu523. Epub 2014 Aug 5. Bioinformatics. 2014. PMID: 25095879 Free PMC article.
In this study, we measure the frequency of different T-cell receptors (TcR) in CD4 + T cell populations of mice immunized with a complex antigen, killed Mycobacterium tuberculosis, using high throughput parallel sequencing of the TcRbeta chain. Our initial hypothesis that …
In this study, we measure the frequency of different T-cell receptors (TcR) in CD4 + T cell populations of mice immunized with a complex ant …
Feature selection using a one dimensional naïve Bayes' classifier increases the accuracy of support vector machine classification of CDR3 repertoires.
Cinelli M, Sun Y, Best K, Heather JM, Reich-Zeliger S, Shifrut E, Friedman N, Shawe-Taylor J, Chain B. Cinelli M, et al. Among authors: chain b. Bioinformatics. 2017 Apr 1;33(7):951-955. doi: 10.1093/bioinformatics/btw771. Bioinformatics. 2017. PMID: 28073756 Free PMC article.
In this study we use high throughput sequencing to compare the global changes in T cell receptor beta chain complementarity determining region 3 (CDR3beta) sequences following immunization with ovalbumin administered with complete Freund's adjuvant (CFA) or CFA alone. ...T …
In this study we use high throughput sequencing to compare the global changes in T cell receptor beta chain complementarity determini …
Quantitative analysis of the T cell receptor repertoire.
Uddin I, Woolston A, Peacock T, Joshi K, Ismail M, Ronel T, Husovsky C, Chain B. Uddin I, et al. Among authors: chain b. Methods Enzymol. 2019;629:465-492. doi: 10.1016/bs.mie.2019.05.054. Epub 2019 Jun 20. Methods Enzymol. 2019. PMID: 31727254
An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.
Peng Y, Felce SL, Dong D, Penkava F, Mentzer AJ, Yao X, Liu G, Yin Z, Chen JL, Lu Y, Wellington D, Wing PAC, Dominey-Foy DCC, Jin C, Wang W, Hamid MA, Fernandes RA, Wang B, Fries A, Zhuang X, Ashley N, Rostron T, Waugh C, Sopp P, Hublitz P, Beveridge R, Tan TK, Dold C, Kwok AJ, Rich-Griffin C, Dejnirattisa W, Liu C, Kurupati P, Nassiri I, Watson RA, Tong O, Taylor CA, Kumar Sharma P, Sun B, Curion F, Revale S, Garner LC, Jansen K, Ferreira RC, Attar M, Fry JW, Russell RA; COMBAT Consortium; Stauss HJ, James W, Townsend A, Ho LP, Klenerman P, Mongkolsapaya J, Screaton GR, Dendrou C, Sansom SN, Bashford-Rogers R, Chain B, Smith GL, McKeating JA, Fairfax BP, Bowness P, McMichael AJ, Ogg G, Knight JC, Dong T. Peng Y, et al. Among authors: chain b. Nat Immunol. 2022 Jan;23(1):50-61. doi: 10.1038/s41590-021-01084-z. Epub 2021 Dec 1. Nat Immunol. 2022. PMID: 34853448 Free PMC article.
278 results